Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer.

Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer. Research Abstract Details 

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Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer. Abstract Text:

S Y Kim,J-L Roh,N-K Yeo,J S Kim,J H Lee,S-H Choi,S Y Nam,S Y Kim,J-L Roh,N-K Yeo,J S Kim,J H Lee,S-H Choi,S Y Nam,S Y Kim,J-L Roh,N-K Yeo,J S Kim,J H Lee,S-H Choi,S Y Nam,

BACKGROUND: The aim of this study was to evaluate the ability of (18)F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) to detect second primary cancers and distant metastases in patients with head and neck cancer (HNC). PATIENTS AND METHODS: Patients with previous untreated HNC, between 2004 and 2005, underwent head and neck CT and whole-body FDG-PET/CT, before and at fixed intervals after therapy, for staging and detection of second primary cancers and distant metastases. Patients with malignant or equivocal findings on FDG-PET/CT underwent further imaging, endoscopy and/or biopsy. RESULTS: Of the 349 eligible patients (267 men and 82 women), 14 (4.0%) had second primary cancers and 26 (7.4%) had distant metastases at initial staging or during mean follow-up of 15 months after treatment. FDG-PET/CT correctly identified second cancers or distant metastases in 39 of these 40 patients; there was one false negative and 23 false positive FDG-PET/CT results. Therefore, FDG-PET/CT had a sensitivity of 97.5%, a specificity of 92.6%, a positive predictive value of 62.9% and a negative predictive value of 99.7% in detecting second primary cancers and distant metastases. CONCLUSION: Combined FDG-PET/CT is useful as a primary method for detecting second cancers and distant metastases in patients with HNC.

Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer. Publishing Authors By Initials

SY Kim,JL Roh,NK Yeo,JS Kim,JH Lee,SH Choi,SY Nam,SY Kim,JL Roh,NK Yeo,JS Kim,JH Lee,SH Choi,SY Nam,SY Kim,JL Roh,NK Yeo,JS Kim,JH Lee,SH Choi,SY Nam,

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Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Annals of oncology : official journal of the Europ

VOLUME: 18

Page Numbers: 1698-703

Journal Abbreviation: Ann. Oncol.

ISSN: 0923-7534

DAY: 22

MONTH: 08

YEAR: 2007

Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer. Information

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LANGUAGE: eng

NlmUniqueID: 9007735

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Grant and Affiliation Information for Combined 18F-fluorodeoxyglucose-positron emission tomography and computed tomography as a primary screening method for detecting second primary cancers and distant metastases in patients with head and neck cancer.

AFFILIATION: Department of Otolaryngology.

Country: England

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MEDLINETA: Ann Oncol

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