Combinations of biomarkers predictive of later life mortality.

Combinations of biomarkers predictive of later life mortality. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Combinations of biomarkers predictive of later life mortality. Abstract Text:

Tara L Gruenewald,Teresa E Seeman,Carol D Ryff,Arun S Karlamangla,Burton H Singer,

A wide range of biomarkers, reflecting activity in a number of biological systems (e.g., neuroendocrine, immune, cardiovascular, and metabolic), have been found to prospectively predict disability, morbidity, and mortality outcomes in older adult populations. Levels of these biomarkers, singly or in combination, may serve as an early warning system of risk for future adverse health outcomes. In the current investigation, 13 biomarkers were examined as predictors of mortality occurrence over a 12-year period in a sample of men and women (n = 1,189) 70-79 years of age at enrollment into the study. Biomarkers examined in analyses included markers of neuroendocrine functioning (epinephrine, norepinephrine, cortisol, and dehydroepiandrosterone), immune activity (C-reactive protein, fibrinogen, IL-6, and albumin), cardiovascular functioning (systolic and diastolic blood pressure), and metabolic activity [high-density lipoprotein (HDL) cholesterol, total to HDL cholesterol ratio, and glycosylated hemoglobin]. Recursive partitioning techniques were used to identify a set of pathways, composed of combinations of different biomarkers, that were associated with a high-risk of mortality over the 12-year period. Of the 13 biomarkers examined, almost all entered into one or more high-risk pathways although combinations of neuroendocrine and immune markers appeared frequently in high-risk male pathways, and systolic blood pressure was present in combination with other biomarkers in all high-risk female pathways. These findings illustrate the utility of recursive partitioning techniques in identifying biomarker combinations predictive of mortal outcomes in older adults, as well as the multiplicity of biological pathways to mortality in elderly populations.

Combinations of biomarkers predictive of later life mortality. Publishing Authors By Initials

TL Gruenewald,TE Seeman,CD Ryff,AS Karlamangla,BH Singer,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Combinations of biomarkers predictive of later life mortality. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 14158-63

Journal Abbreviation:

ISSN: 0027-8424

DAY: 18

MONTH: 09

YEAR: 2006

Combinations of biomarkers predictive of later life mortality. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Combinations of biomarkers predictive of later life mortality. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Combinations of biomarkers predictive of later life mortality. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Combinations of biomarkers predictive of later life mortality.

AFFILIATION: Department of Medicine/Geriatrics, University of California, Los Angeles, CA 90095-1687, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Combinations of biomarkers predictive of later life mortality Related Publications

• A longitudinal case study of a child with mosaic trisomy 22: language, cognitive, behavioral, physical, and dental outcomes.
• A progressive, fatal dystonia-Parkinsonism syndrome in a patient with primary immunodeficiency receiving chronic IVIG therapy.
• A recipe for randomness.
• Aggressive drug marketing tactics trigger backlash.
• Bupropion for smokers hospitalized with acute cardiovascular disease.
• Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma.
• Combinations of biomarkers predictive of later life mortality.
• Constitutive turnover of cyclin E by Cul3 maintains quiescence.
• Detection and Classification of Movements in Bed using Load Cells.
• Education correction using years in school or reading grade-level equivalent? Comparing the accuracy of two methods in diagnosing HIV-associated neurocognitive impairment.
• Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis.
• In vivo dynamics of RNA polymerase II transcription.
• Laryngeal dystonia as a presenting symptom of young-onset Parkinson's disease.
• Mast cell-mediated changes in smooth muscle contractility during mouse giardiasis.
• Metastasis to the submandibular gland in head and neck carcinomas.
• Norepinephrine transporter polymorphisms in Tourette syndrome with and without attention deficit hyperactivity disorder: no evidence for significant association.
• Postdischarge treatment costs following closure of a state geropsychiatric ward: comparison of 2 levels of community care.
• Prenatal cocaine and tobacco effects on children's language trajectories.
• Role of the brain-gut axis in alcohol-related gastrointestinal diseases--what can we learn from new animal models?
• Selective effects of cyclosporin A on colony-forming lymphoid and myeloid cells in man.
• Sleep and sleep disturbance: from genes to dreams.
• The Cullin3 ubiquitin ligase functions as a Nedd8-bound heterodimer.
• The aging experience of well elderly women: initial results.
• The headache doctor: the dog ate my pills and other tales of woe.
• The validity of the 2004 U.S. News & World Report's rankings of schools of social work: a response.
• Tic disorders: neural circuits, neurochemistry, and neuroimmunology.
• Tumour necrosis factor alpha contributes to protection against Giardia lamblia infection in mice.
• Within-trial contrast: pigeons prefer conditioned reinforcers that follow a relatively more rather than a less aversive event.
• [Ectopic prostatic tissue in the uterine cervix]
• [Meningothelial meningioma in a mature cystic teratoma of the ovary]