Collagen types I and III in giant papillae of vernal keratoconjunctivitis.

Collagen types I and III in giant papillae of vernal keratoconjunctivitis. Research Abstract Details 

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Collagen types I and III in giant papillae of vernal keratoconjunctivitis. Abstract Text:

AIMS--The objective of this study was to investigate alterations in conjunctival collagen and proteoglycans in the conjunctival giant papillae of patients with vernal keratoconjunctivitis (VKC). METHODS--Tissue samples from tarsal giant papillae of seven eyes from five patients with VKC, and five tarsal conjunctival samples from five normal patients were obtained. Tissues were processed and stained with haematoxylin and eosin, Van Gieson, trichromic Mallory, toluidine blue, Alcian blue, and alkaline Giemsa. Collagen extraction was performed in acetic acid and pepsin, total collagen was quantified using hydroxy-proline levels, and collagen types I and III were analysed by gel electrophoresis (SDS-PAGE). Proteoglycans were quantified using uronic acid levels. RESULTS--Histological evaluation showed a significant increase of mast cells in the epithelium (0/mm2 v 147/mm2, p < 0.01) and in the stroma (5.1/mm2 v 80/mm2, p < 0.01) of VKC patients. Collagen fibres were thicker and arranged irregularly, with the total amount significantly increased. Owing to an increased percentage of type III collagen, the ratio of collagen types I to III was decreased. Proteoglycans were also reduced in VKC samples. CONCLUSION--The well known morphological abnormalities observed in VKC correspond to alterations in the ratio between collagens and proteoglycans, and between different types of collagen. The greatly increased number of mast cells found in these tissues suggests an active role for these cells in the abnormal connective tissue metabolism observed in VKC.

Collagen types I and III in giant papillae of vernal keratoconjunctivitis. Publishing Authors By Initials

For similar carbohydrates: polysaccharides: proteoglycans research abstracts see: carbohydrates: polysaccharides: proteoglycans research

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Collagen types I and III in giant papillae of vernal keratoconjunctivitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The British journal of ophthalmology

VOLUME: 79

Page Numbers: 482-5

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: May

YEAR: 1995

Collagen types I and III in giant papillae of vernal keratoconjunctivitis. Information

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LANGUAGE: eng

NlmUniqueID: 421041

Collagen types I and III in giant papillae of vernal keratoconjunctivitis. Keywords Mesh Terms:

KEYWORDS: Proteoglycans

MESH TERMS: analysis

Chemical & Substance for Abstract: Collagen types I and III in giant papillae of vernal keratoconjunctivitis. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Collagen types I and III in giant papillae of vernal keratoconjunctivitis.

AFFILIATION: Institute of Ophthalmology, University of Padova, Italy.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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