Colesevelam: a review of its use in hypercholesterolemia.

Colesevelam: a review of its use in hypercholesterolemia. Research Abstract Details 

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Colesevelam: a review of its use in hypercholesterolemia. Abstract Text:

Dean M Robinson,Gillian M Keating,Dean M Robinson,Gillian M Keating,

Colesevelam hydrochloride (Cholestagel((R)), WelChol((R))) is an orally administered, non-absorbable, polymeric, bile-acid-binding agent with a higher affinity for glycocholic acid in vitro and greater capacity for binding bile acids in vivo than other bile-acid-binding agents.In randomized controlled trials in patients with primary hypercholesterolemia, colesevelam monotherapy reduced mean serum low-density lipoprotein-cholesterol (LDL-C) levels by 9-19%. In combination with an HMG-CoA reductase inhibitor (statin) or fenofibrate, colesevelam induced additive reductions in LDL-C 10-16% greater than those achieved by monotherapy with a statin (in patients with primary hypercholesterolemia) or fenofibrate (in patients with mixed hyperlipidemia). Colesevelam was generally well tolerated, with a relatively low incidence of gastrointestinal adverse events and a high compliance rate. Thus, colesevelam provides a useful addition to primary therapy with statins in the treatment of primary hypercholesterolemia, or fenofibrate in the treatment of mixed hyperlipidemia.

Colesevelam: a review of its use in hypercholesterolemia. Publishing Authors By Initials

DM Robinson,GM Keating,DM Robinson,GM Keating,

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Colesevelam: a review of its use in hypercholesterolemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of cardiovascular drugs : drugs,

VOLUME: 7

Page Numbers: 453-65

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ISSN: 1175-3277

DAY: 13

MONTH: 12

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Wolters Kluwer Health | Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Conshohocken, Pennsylvania, USA.

Country: New Zealand

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MEDLINETA: Am J Cardiovasc Drugs

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