Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type.

Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type. Research Abstract Details 

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Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type. Abstract Text:

Anil Kumar,Neha Seghal,Pattipati S Naidu,Satyanaryana S Padi,Richa Goyal,Anil Kumar,Neha Seghal,Pattipati S Naidu,Satyanaryana S Padi,Richa Goyal,

Alzheimer's disease (AD) is the most common type of dementia disorder of elderly affecting millions of people. The pathophysiology of the disease is complex and involves multiple pathways of neuronal damage. Sporadic dementia of Alzheimer's type (SDAT) has been shown to be associated with microtubular dysfunction and is characterized by the appearance of specific cytoskeletal cellular abnormalities, including neurofibrillary tangles and senile plaques. Intracerebroventricular (i.c.v) administration of colchicine, a microtubule-disrupting agent, causes cognitive dysfunction as evidenced by poor retention of memory in both Morris water maze and elevated plus-maze task paradigms that is associated with excessive free radical generation. Biochemical analysis revealed that icv colchicine injection significantly induced lipid peroxidation, increased nitrite and depleted reduced glutathione (GSH) and acetylcholinesterase (AChE) level in rat brains. Chronic treatment with rivastigmine (0.625 and 2.5 mg/kg, po) twice daily for a period of 25 days beginning 4 days prior to colchicine injection significantly improved the colchicine-induced cognitive impairment and reduced AChE level. The results of the present study clearly indicated that colchicines-induced cognitive impairment and oxidative stress in animals and can be used as an animal model for drug screening for Alzheimer's disease.

Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type. Publishing Authors By Initials

A Kumar,N Seghal,PS Naidu,SS Padi,R Goyal,A Kumar,N Seghal,PS Naidu,SS Padi,R Goyal,

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PUBMED ID PMID:

MEDLINE DATE: 2007 May-Jun

Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmacological reports : PR

VOLUME: 59

Page Numbers: 274-83

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ISSN: 1734-1140

DAY: 26

MONTH: 07

YEAR: 2007

Colchicines-induced neurotoxicity as an animal model of sporadic dementia of Alzheimer's type. Information

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LANGUAGE: eng

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AFFILIATION: Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India. kumaruips@yahoo.com

Country: Poland

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MEDLINETA: Pharmacol Rep

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