Coherent neural representation of hand speed in humans revealed by MEG imaging.

Coherent neural representation of hand speed in humans revealed by MEG imaging. Research Abstract Details 

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Coherent neural representation of hand speed in humans revealed by MEG imaging. Abstract Text:

Karim Jerbi,Jean-Philippe Lachaux,Karim N'Diaye,Dimitrios Pantazis,Richard M Leahy,Line Garnero,Sylvain Baillet,

The spiking activity of single neurons in the primate motor cortex is correlated with various limb movement parameters, including velocity. Recent findings obtained using local field potentials suggest that hand speed may also be encoded in the summed activity of neuronal populations. At this macroscopic level, the motor cortex has also been shown to display synchronized rhythmic activity modulated by motor behavior. Yet whether and how neural oscillations might be related to limb speed control is still poorly understood. Here, we applied magnetoencephalography (MEG) source imaging to the ongoing brain activity in subjects performing a continuous visuomotor (VM) task. We used coherence and phase synchronization to investigate the coupling between the estimated activity throughout the brain and the simultaneously recorded instantaneous hand speed. We found significant phase locking between slow (2- to 5-Hz) oscillatory activity in the contralateral primary motor cortex and time-varying hand speed. In addition, we report long-range task-related coupling between primary motor cortex and multiple brain regions in the same frequency band. The detected large-scale VM network spans several cortical and subcortical areas, including structures of the frontoparietal circuit and the cerebello-thalamo-cortical pathway. These findings suggest a role for slow coherent oscillations in mediating neural representations of hand kinematics in humans and provide further support for the putative role of long-range neural synchronization in large-scale VM integration. Our findings are discussed in the context of corticomotor communication, distributed motor encoding, and possible implications for brain-machine interfaces.

Coherent neural representation of hand speed in humans revealed by MEG imaging. Publishing Authors By Initials

K Jerbi,JP Lachaux,K N'Diaye,D Pantazis,RM Leahy,L Garnero,S Baillet,

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Coherent neural representation of hand speed in humans revealed by MEG imaging. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 7676-81

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ISSN: 0027-8424

DAY: 18

MONTH: 04

YEAR: 2007

Coherent neural representation of hand speed in humans revealed by MEG imaging. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Coherent neural representation of hand speed in humans revealed by MEG imaging. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiology

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Grant and Affiliation Information for Coherent neural representation of hand speed in humans revealed by MEG imaging.

AFFILIATION: Cognitive Neuroscience and Brain Imaging Laboratory, Centre National de la Recherche Scientifique, UPR-640 Lena, MEG Center, Université Pierre et Marie Curie (Paris 6), Hôpital de la Salpêtrière, 75013 Paris, France. karim.jerbi@lyon.inserm.fr

Country: United States

AGENCY: United States NIBIB

GRANT: R01 EB002010

ACRONYM: EB

MEDLINETA: Proc Natl Acad Sci U S A

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