The aim of this study was to identify characteristics of neuropsychological functioning among type 2 diabetic adults with and without major depression. Twenty type 2 diabetics with major depression, 20 non-depressed type 2 diabetics and 34 controls without diabetes or depression were compared. A mixed effects repeated measures analysis of covariance indicated significant differences in overall cognitive functioning between diagnostic groups, specifically depressed diabetics demonstrated greater cognitive dysfunction than controls. Further comparisons indicated that depressed diabetics performed significantly worse than non-depressed diabetics in attention/information processing speed. Relative to controls, depressed diabetics performed significantly worse in attention/information processing speed and executive functioning, while there was a trend for non-depressed diabetics to perform worse in executive functioning. These findings suggest that depression negatively impacts cognitive performance among adults with type 2 diabetes, which may have implications for neural circuitry underlying cognitive and mood changes in diabetic patients.
Cognitive function in adults with type 2 diabetes and major depression. Publishing Authors By Initials
Cognitive function in adults with type 2 diabetes and major depression. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Archives of clinical neuropsychology : the officia
VOLUME: 21
Page Numbers: 787-96
Journal Abbreviation:
ISSN: 0887-6177
DAY: 9
MONTH: 10
YEAR: 2006
Cognitive function in adults with type 2 diabetes and major depression. Information
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LANGUAGE: eng
NlmUniqueID: 9004255
Cognitive function in adults with type 2 diabetes and major depression. Keywords Mesh Terms:
KEYWORDS: Space Perception
MESH TERMS: physiology
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Grant and Affiliation Information for Cognitive function in adults with type 2 diabetes and major depression.
AFFILIATION: Division of Geriatric Psychiatry, UCLA Semel Institute & Resnick Neuropsychiatric Hospital, 760 Westwood Plaza, 37-372A, Los Angeles, CA 90024-1759, United States. kwatari@mednet.ucla.edu
Country: United States
AGENCY: United States NIMH
GRANT: R01-MH-63674
ACRONYM: MH
MEDLINETA: Arch Clin Neuropsychol
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