Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control.

Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control. Abstract Text:

Melissa L Hwang,John R Lukens,Timothy N J Bullock,Melissa L Hwang,John R Lukens,Timothy N J Bullock,

CD4(+) T cells are known to provide support for the activation and expansion of primary CD8(+) T cells, their subsequent differentiation, and ultimately their survival as memory cells. However, the importance of cognate memory CD4(+) T cells in the expansion of memory CD8(+) T cells after re-exposure to Ag has been not been examined in detail. Using bone marrow-derived dendritic cells pulsed with cognate or noncognate MHC class I- and class II-restricted peptides, we examined whether the presence of memory CD4(+) T cells with the same Ag specificity as memory CD8(+) T cells influenced the quantity and quality of the secondary CD8(+) T cell response. After recombinant vaccinia virus-mediated challenge, we demonstrate that, although cognate memory CD4(+) T cells are not required for activation of secondary CD8(+) T cells, their presence enhances the expansion of cognate memory CD8(+) T cells. Cognate CD4(+) T cell help results in an approximate 2-fold increase in the frequency of secondary CD8(+) T cells in secondary lymphoid tissues, and can be accounted for by enhanced proliferation in the secondary CD8(+) T cell population. In addition, cognate memory CD4(+) T cells further selectively enhance secondary CD8(+) T cell infiltration of tumor-associated peripheral tissue, and this is accompanied by increased differentiation into effector phenotype within the secondary CD8(+) T cell population. The consequence of these improvements to the magnitude and phenotype of the secondary CD8(+) T cell response is substantial increase in control of tumor outgrowth.

Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control. Publishing Authors By Initials

ML Hwang,JR Lukens,TN Bullock,ML Hwang,JR Lukens,TN Bullock,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 5829-38

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 1

MONTH: Nov

YEAR: 2007

Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985117

Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control.

AFFILIATION: Department of Pathology, Human Immune Therapy Center, University of Virginia Health System, Charlottesville, VA 22908, USA.

Country: United States

AGENCY: United States NCI

GRANT: K01 CA-95093

ACRONYM: CA

MEDLINETA: J Immunol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control Related Publications

• A review of research literature addressing male partners and smoking during pregnancy.
• An iron catalyst for ketone hydrogenations under mild conditions.
• Analyses of the interaction between the origin binding domain from simian virus 40 T antigen and single-stranded DNA provide insights into DNA unwinding and initiation of DNA replication.
• Assessment of mitochondrial impairment in traumatic brain injury using high-resolution proton magnetic resonance spectroscopy.
• Carbon-to-metal hydrogen atom transfer: direct observation using time-resolved infrared spectroscopy.
• Cognate memory CD4+ T cells generated with dendritic cell priming influence the expansion, trafficking, and differentiation of secondary CD8+ T cells and enhance tumor control.
• Comparative physiology of acoustic and allied central analyzers.
• Detection of rifampicin binding immunoglobulins.
• Diagnosis and management of irritable bowel syndrome in adults in primary care: summary of NICE guidance.
• Effect of lactate therapy upon cognitive deficits after traumatic brain injury in the rat.
• Efficacy of 100 consecutive right ventricular endomyocardial biopsies in pediatric patients using the right internal jugular venous approach.
• Endodermal sinus and other yolk sac tumours, a reappraisal.
• Grandfathers raising grandchildren:an exploration of african american kinship networks.
• Histochemical studies on the Acanthocephala; the distribution of glycogen and fatty substances.
• Histochemical studies on the Acanthocephala; the distribution of lipase and phosphatase.
• Is there a sex or race difference in stroke mortality?
• Lactate, not glucose, up-regulates mitochondrial oxygen consumption both in sham and lateral fluid percussed rat brains.
• Model for T-antigen-dependent melting of the simian virus 40 core origin based on studies of the interaction of the beta-hairpin with DNA.
• Model of traveling waves in a coral nerve network.
• Neuropeptide co-release with GABA may explain functional non-monotonic uncertainty responses in dopamine neurons.
• Protection of mitochondrial function and improvement in cognitive recovery in rats treated with hyperbaric oxygen following lateral fluid-percussion injury.
• Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
• Resources for evidence-based practice.
• Spatially embedded random networks.
• Systematic review: Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia.
• The Philadelphia Program for Home Psychiatric Evaluations, Precare, and Involuntary Hospitalization.
• The Talking Sex Project: descriptions of the study population and correlates of sexual practices at baseline.
• The vulnerablility for elder abuse among a sample of custodial grandfathers:an exploratory study.
• Update on male urinary stress incontinence.
• Zelda Foster and her contributions to social work in end-of-life care.