Coevolution of robustness, epistasis, and recombination favors asexual reproduction.

Coevolution of robustness, epistasis, and recombination favors asexual reproduction. Research Abstract Details 

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Coevolution of robustness, epistasis, and recombination favors asexual reproduction. Abstract Text:

Thomas MacCarthy,Aviv Bergman,

The prevalence of sexual reproduction remains one of the most perplexing phenomena in evolutionary biology. The deterministic mutation hypothesis postulates that sexual reproduction will be advantageous under synergistic epistasis, a condition in which mutations cause a greater reduction in fitness when combined than would be expected from their individual effects. The inverse condition, antagonistic epistasis, correspondingly is predicted to favor asexual reproduction. To assess this hypothesis, we introduce a finite population evolutionary process that combines a recombination modifier formalism with a gene-regulatory network model. We demonstrate that when reproductive mode and epistasis are allowed to coevolve, asexual reproduction outcompetes sexual reproduction. In addition, no correlation is found between the level of synergistic epistasis and the fixation time of the asexual mode. However, a significant correlation is found between the level of antagonistic epistasis and asexual mode fixation time. This asymmetry can be explained by the greater reduction in fitness imposed by sexual reproduction as compared with asexual reproduction. Our findings present evidence and suggest plausible explanations that challenge both the deterministic mutation hypothesis and recent arguments asserting the importance of emergent synergistic epistasis in the maintenance of sexual reproduction.

Coevolution of robustness, epistasis, and recombination favors asexual reproduction. Publishing Authors By Initials

T MacCarthy,A Bergman,

For similar reproductive and urinary physiology: reproduction: reproduction, asexual research abstracts see: reproductive and urinary physiology: reproduction: reproduction, asexual research

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Coevolution of robustness, epistasis, and recombination favors asexual reproduction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 12801-6

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 23

MONTH: 07

YEAR: 2007

Coevolution of robustness, epistasis, and recombination favors asexual reproduction. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

Coevolution of robustness, epistasis, and recombination favors asexual reproduction. Keywords Mesh Terms:

KEYWORDS: Reproduction, Asexual

MESH TERMS: physiology

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Grant and Affiliation Information for Coevolution of robustness, epistasis, and recombination favors asexual reproduction.

AFFILIATION: Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Country: United States

AGENCY: United States NIA

GRANT: R01 AG 028872-01A1

ACRONYM: AG

MEDLINETA: Proc Natl Acad Sci U S A

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