Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children.

Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Research Abstract Details 

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Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Abstract Text:

G Campisi,C Di Liberto,A Carroccio,D Compilato,G Iacono,M Procaccini,G Di Fede,L Lo Muzio,A Craxi,C Catassi,C Scully,G Campisi,C Di Liberto,A Carroccio,D Compilato,G Iacono,M Procaccini,G Di Fede,L Lo Muzio,A Craxi,C Catassi,C Scully,

AIMS: Oral mucosal lesions may be markers of chronic gastrointestinal disorders, such as those causing malabsorption. Our objectives were to assess the prevalence of recurrent oral aphthous-like ulcers in coeliac disease patients living in the Mediterranean area, and to evaluate the impact of a gluten-free diet. METHODS: A test group of 269 patients (age range 3-17 years) with coeliac disease confirmed both serologically and histologically was compared with a control group of 575 otherwise clinically healthy subjects for the presence, or a positive history of aphthous-like ulcers. Coeliac disease patients with aphthous-like ulcers were re-evaluated 1-year after starting a gluten-free diet. RESULTS: Aphthous-like ulcers were found significantly more frequently in coeliac disease, in 22.7% (61/269) of patients with coeliac disease versus 7.1% (41/575) of controls (p=<0.0001; chi-square=41.687; odds ratio=4.3123; 95% confidence interval=2.7664:6.722). Most coeliac disease patients with aphthous-like ulcers and adhering strictly to gluten-free diet (71.7%; 33/46) reported significant improvement on gluten-free diet, with no or reduced episodes of aphthous-like ulcers (p=0.0003; chi-square=13.101; odds ratio=24.67; 95% confidence interval=2.63:231.441). CONCLUSIONS: The epidemiological association found between coeliac disease and aphthous-like ulcers suggests that recurrent aphthous-like ulcers should be considered a risk indicator for coeliac disease, and that gluten-free diet leads to ulcer amelioration.

Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Publishing Authors By Initials

G Campisi,C Di Liberto,A Carroccio,D Compilato,G Iacono,M Procaccini,G Di Fede,L Lo Muzio,A Craxi,C Catassi,C Scully,G Campisi,C Di Liberto,A Carroccio,D Compilato,G Iacono,M Procaccini,G Di Fede,L Lo Muzio,A Craxi,C Catassi,C Scully,

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Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Digestive and liver disease : official journal of

VOLUME: 40

Page Numbers: 104-7

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ISSN: 1590-8658

DAY: 11

MONTH: 12

YEAR: 2007

Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children.

AFFILIATION: Department of Oral Sciences, University Hospital of Palermo, Palermo, Italy.

Country: Netherlands

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MEDLINETA: Dig Liver Dis

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