Cochlear and renal pathology in the autoimmune strain mouse.

Cochlear and renal pathology in the autoimmune strain mouse. Research Abstract Details 

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Cochlear and renal pathology in the autoimmune strain mouse. Abstract Text:

C Tago,N Yanagita,

This study was designed to investigate the role of immunologic mechanisms in sensorineural hearing disorders and the relationship between inner ear and renal disorders. Autoimmune strain (NZB/kl) mice, in which autoimmune disease can be spontaneously induced, were used in this study. The mice were tested for acoustic brain stem responses, cochlear and renal disorders, and circulating immune complex serology by means of enzyme immunoassay. Pathologic studies consisted of observation of tissue changes following hematoxylin and eosin staining and indirect immunofluorescence staining under light microscopy. Compared to controls, the hearing was impaired in NZB/kl mice. Indirect fluorescence staining showed immunoglobulin G deposits in the stria vascularis. There was a correlation between the degree of hearing impairment and the severity of stria vascularis lesions. The NZB/kl mouse can provide a model for sensorineural hearing disorders secondary to immunologic disorders.

Cochlear and renal pathology in the autoimmune strain mouse. Publishing Authors By Initials

C Tago,N Yanagita,

For similar animals: animal population groups: animals, inbred strains: mice, inbred strains research abstracts see: animals: animal population groups: animals, inbred strains: mice, inbred strains research

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Cochlear and renal pathology in the autoimmune strain mouse. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Annals of otology, rhinology & laryngology. Su

VOLUME: 157

Page Numbers: 87-91

Journal Abbreviation:

ISSN: 0096-8056

DAY: 21

MONTH: Oct

YEAR: 1992

Cochlear and renal pathology in the autoimmune strain mouse. Information

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LANGUAGE: eng

NlmUniqueID: 1256156

Cochlear and renal pathology in the autoimmune strain mouse. Keywords Mesh Terms:

KEYWORDS: Mice, Inbred Strains

MESH TERMS: pathology

Chemical & Substance for Abstract: Cochlear and renal pathology in the autoimmune strain mouse. Information

Substance Name: Immunoglobulin G

Registry Number: 0

Grant and Affiliation Information for Cochlear and renal pathology in the autoimmune strain mouse.

AFFILIATION: Department of Otorhinolaryngology, School of Medicine, Nagoya University, Japan.

Country: UNITED STATES

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MEDLINETA: Ann Otol Rhinol Laryngol Suppl

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