Cocaine increases immunoglobulin heavy chain binding protein and caspase-12 expression in the rat dorsal striatum.

Cocaine increases immunoglobulin heavy chain binding protein and caspase-12 expression in the rat dorsal striatum. Research Abstract Details 

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Cocaine increases immunoglobulin heavy chain binding protein and caspase-12 expression in the rat dorsal striatum. Abstract Text:

Sung Min Ahn,Soo Woon Kim,Eun Sang Choe,Sung Min Ahn,Soo Woon Kim,Eun Sang Choe,Sung Min Ahn,Soo Woon Kim,Eun Sang Choe,

RATIONALE: Cocaine increases endoplasmic reticulum (ER) stress protein expression via glutamate and dopamine receptor activation in the dorsal striatum. OBJECTIVES: The present study was performed to investigate ER stress response in the dorsal striatum in response to acute or repeated cocaine stimulation. It was hypothesized that cocaine upregulates the ER stress protein immunoglobulin heavy chain binding protein (BiP) and the ER stress-associated protein caspase-12 via N-methyl-D: -aspartate (NMDA) and D1 dopamine receptor activation. MATERIALS AND METHODS: Western immunoblot and immunohistochemical analyses were mainly performed to test this hypothesis in the rat dorsal striatum. RESULTS: The results showed that BiP and caspase-12 immunoreactivities were significantly increased at 30, 60, and 120 min after acute or repeated intraperitoneal (i.p.) injections of three doses (10, 20, 40 mg/kg) of cocaine for seven consecutive days. Intrastriatal (i.s.) infusion of the selective NMDA antagonist MK801 (2 nmol) or AP5 (2 nmol) significantly attenuated the increase in the immunoreactivity of caspase-12 in the dorsal striatum induced by repeated, but not acute, cocaine (20 mg/kg) administration. However, i.p. injection of the selective D1 antagonist SCH23390 (0.1 mg/kg) significantly attenuated the increase in the immunoreactivity of caspase-12 in the dorsal striatum induced by both acute and repeated cocaine (20 mg/kg) stimulation. CONCLUSION: These findings suggest that acute or repeated cocaine administration can cause ER stress response in the dorsal striatum in which NMDA and D1 dopamine receptors participate in the mediation of the process.

Cocaine increases immunoglobulin heavy chain binding protein and caspase-12 expression in the rat dorsal striatum. Publishing Authors By Initials

SM Ahn,SW Kim,ES Choe,SM Ahn,SW Kim,ES Choe,SM Ahn,SW Kim,ES Choe,

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Cocaine increases immunoglobulin heavy chain binding protein and caspase-12 expression in the rat dorsal striatum. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychopharmacology

VOLUME: 195

Page Numbers: 407-14

Journal Abbreviation: Psychopharmacology (Berl.)

ISSN: 0033-3158

DAY: 13

MONTH: 09

YEAR: 2007

Cocaine increases immunoglobulin heavy chain binding protein and caspase-12 expression in the rat dorsal striatum. Information

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LANGUAGE: eng

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AFFILIATION: Division of Biological Sciences, Pusan National University, 30 Jangjeon-dong, Kumjeong-gu, Pusan, 609-735, South Korea, eschoe@pusan.ac.kr.

Country: Germany

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MEDLINETA: Psychopharmacology (Berl)

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