Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations.

Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations. Abstract Text:

Cocaine abuse in methadone maintenance patients has emerged as a significant clinical problem. To determine if raising the daily methadone dosage is an effective way to eliminate cocaine abuse, 74 methadone maintenance patients maintained at daily dosages between 30 and 80 mg and who chronically abused cocaine were studied by a standard protocol. A total of 21 (28.4%) subjects ceased cocaine abuse when their methadone dosage was progressively raised to a maximal daily dose of 160 mg. Cocaine abuse appeared to accelerate elimination of methadone, since inadequate methadone serum concentrations (below 100 ng/ml) were found in 48 of 67 (71.6%) subjects tested 24 hours after a 100 mg oral methadone dose. Although cocaine abuse in methadone maintenance patients may respond to raising the daily methadone dosage, alternative treatments for cocaine abuse in methadone maintenance patients must be identified since cocaine abuse may lower serum methadone concentrations.

Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations. Publishing Authors By Initials

For similar disorders of environmental origin: substance-related disorders research abstracts see: disorders of environmental origin: substance-related disorders research

PUBMED ID PMID:

MEDLINE DATE:

Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of addictive diseases

VOLUME: 14

Page Numbers: 67-74

Journal Abbreviation:

ISSN: 1055-0887

DAY: 12

MONTH: 05

YEAR: 1995

Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107051

Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations. Keywords Mesh Terms:

KEYWORDS: Substance-Related Disorders

MESH TERMS: rehabilitation

Chemical & Substance for Abstract: Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations. Information

Substance Name: Methadone

Registry Number: 76-99-3

Grant and Affiliation Information for Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations.

AFFILIATION: Research Center for Dependency Disorders and Chronic Pain, Community Health Projects, Inc., West Covina, CA 91790, USA.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Addict Dis

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Cocaine abuse in methadone maintenance patients is associated with low serum methadone concentrations Related Publications

• A 6-item brief measure for assessing perceived control of asthma in culturally diverse patients.
• A conceptual application of health behavior theory in the design and implementation of a successful surgical weight loss program.
• A diruthenium-substituted polyoxometalate as an electrocatalyst for oxygen generation.
• Achieving form and function for Class II restorations: a simplified technique.
• Aflatoxins B1, B2, G1, and G2: separation and purification.
• Aging is associated with myocardial insulin resistance and mitochondrial dysfunction.
• Apparatus for measuring the finite load-deformation behavior of a sheet of epithelial cells cultured on a mesoscopic freestanding elastomer membrane.
• Asthma burden in a citywide, diverse sample of elementary schoolchildren in Chicago.
• Biochemical and functional characterization of germ line KRAS mutations.
• Case holding in out-patient therapy of syphilis; a study of case-holding experiences in the out-patient management of patients treated with penicillin on an ambulatory basis.
• Combined effects of frequency compression-expansion and shift on speech recognition.
• Deregulated Ras signaling in developmental disorders: new tricks for an old dog.
• Development and validation of the maximal electro-shock seizure model in dogs.
• Did you get an 'A'?
• Does time of measurement effect peak blood lactate following maximal exercise?: 1604: board #94 may 30 2:00 PM - 3:30 PM.
• Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung.
• Emergency care for children in pediatric and general emergency departments.
• Hereditary hemorrhagic telangiectasia and rutin.
• Improving medication compliance in patients with heart failure.
• Linking calsequestrin to lumenal control of SR Ca2+ release.
• Misoprostol associated refractile material in fetal and placental tissues after medical termination of pregnancy.
• Natural history of acoustic neuromas.
• Nutritional aspects of child and adolescent psychopharmacology.
• Patterns of workplace harassment, gender, and use of services: an update.
• Retinoblastoma, retinal glioma, cured by radon seeds; report of a case.
• Risky sexual behavior among women with protective orders against violent male partners.
• THE EFFECT OF EXPOSING STANNOUS FLUORIDE-TREATED ENAMEL SURFACES TO WHOLE SALIVA.
• Targeting oncogenic Ras.
• The establishment of health maintenance organizations: a geographical analysis.
• Tubulovillous adenoma of the prostatic urethra: a rare and usually indolent lesion distinct from prostatic adenocarcinoma.