Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis.

Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis. Abstract Text:

Byung Ha Lee,Jung Eun Lee,Kwang Woong Lee,Hye Yeong Nam,Hyun Jung Jeon,Young Ju Sung,Jong Sung Kim,Hyun Jung Lim,Jong-Sang Park,Jai Young Ko,Dae Joong Kim,Byung Ha Lee,Jung Eun Lee,Kwang Woong Lee,Hye Yeong Nam,Hyun Jung Jeon,Young Ju Sung,Jong Sung Kim,Hyun Jung Lim,Jong-Sang Park,Jai Young Ko,Dae Joong Kim,

BACKGROUND: Most commonly resulting from intimal hyperplasia at the venous anastomosis, stenosis leading to thrombosis is a major cause of failure of polytetrafluoroethylene (PTFE) dialysis grafts. We recently reported that coating haemodialysis grafts with paclitaxel could reduce neointimal hyperplasia. This study tested whether paclitaxel-coating could prolong graft survival in a porcine model. METHODS: PTFE grafts were double-coated with paclitaxel. Bilateral grafts were created between the carotid arteries and the external jugular veins, and we evaluated graft survival by weekly measurements of blood flow for 12 weeks. RESULTS: We successfully implanted four pairs of paclitaxel-coated grafts and four pairs of control grafts in eight Landrace pigs. One control pig had to be euthanized at 4 weeks after graft placement. The grafts in the other three controls and four paclitaxel pigs survived until harvesting of the grafts. All paclitaxel-coated grafts remained patent for 12 weeks without decrease of blood flow. Median blood flow was 702 ml/min at three weeks and 818 ml/min at 12 weeks after placement. In contrast, the four control grafts lost luminal patency at 5, 6, 6 and 8 weeks, respectively. In Kaplan-Meier analysis, paclitaxel-coated grafts showed better survival than uncoated grafts (P = 0.011). CONCLUSIONS: Double-coating with paclitaxel improved graft survival. Coated PTFE grafts may be effective for the prevention of graft failure in patients on haemodialysis.

Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis. Publishing Authors By Initials

BH Lee,JE Lee,KW Lee,HY Nam,HJ Jeon,YJ Sung,JS Kim,HJ Lim,JS Park,JY Ko,DJ Kim,BH Lee,JE Lee,KW Lee,HY Nam,HJ Jeon,YJ Sung,JS Kim,HJ Lim,JS Park,JY Ko,DJ Kim,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Nephrology, dialysis, transplantation : official p

VOLUME: 22

Page Numbers: 2800-4

Journal Abbreviation: Nephrol. Dial. Transplant.

ISSN: 0931-0509

DAY: 7

MONTH: 07

YEAR: 2007

Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8706402

Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis.

AFFILIATION: Division of Nephrology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, Korea 135-710.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Nephrol Dial Transplant

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Coating with paclitaxel improves graft survival in a porcine model of haemodialysis graft stenosis Related Publications

• Aberrant expression of MUC3 and MUC4 membrane-associated mucins and sialyl Le(x) antigen in pancreatic intraepithelial neoplasia.
• Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.
• Advanced capabilities for future light sources.
• Aging of the population and the subsequent increase in the mistreatment of the elderly in Korea.
• Alkali-catalyzed beta-elimination of periodate-oxidized glycans: a novel method of chemical deglycosylation of mucin gene products in paraffin embedded sections.
• Altered mucin core peptide immunoreactivity in the colon polyp-carcinoma sequence.
• Basic fibroblast growth factor-induced translocation of p21-activated kinase to the membrane is independent of phospholipase C-gamma1 in the differentiation of PC12 cells.
• Biological properties and expression of mucins in 5-fluorouracil resistant HT29 human colon cancer cells.
• Cholangiocarcinomas arising in cirrhosis and combined hepatocellular-cholangiocellular carcinomas share apomucin profiles.
• Chromosomal clustering of muscle-expressed genes in Caenorhabditis elegans.
• Drynariae Rhizoma promotes osteoblast differentiation and mineralization in MC3T3-E1 cells through regulation of bone morphogenetic protein-2, alkaline phosphatase, type I collagen and collagenase-1.
• Elderly Women's Grief in Korea.
• Expression of MUC2, MUC5AC and MUC6 apomucins in carcinoma, dysplasia and non-dysplastic epithelia of the gallbladder.
• Goblet cell-specific expression mediated by the MUC2 mucin gene promoter in the intestine of transgenic mice.
• Identification and characterization of the MUC2 (human intestinal mucin) gene 5'-flanking region: promoter activity in cultured cells.
• Immunohistochemical study of mucin carbohydrates and core proteins in hepatolithiasis and cholangiocarcinoma.
• Induction of mucin gene expression in middle ear of rats by tumor necrosis factor-alpha: potential cause for mucoid otitis media.
• Initiation of transcription of the MUC3A human intestinal mucin from a TATA-less promoter and comparison with the MUC3B amino terminus.
• MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region.
• Methylation status of promoters and expression of MUC2 and MUC5AC mucins in pancreatic cancer cells.
• Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor.
• Monoclonal antibodies against partially deglycosylated colon cancer mucin that recognize Tn antigen.
• Mouse intestinal goblet cells expressing SV40 T antigen directed by the MUC2 mucin gene promoter undergo apoptosis upon migration to the villi.
• Optical design of the U7 undulator beamline at the Pohang Light Source.
• Phorbol 12-myristate 13-acetate induces alteration in mucin gene expression and biological properties of colon cancer cells.
• Phorbol 12-myristate 13-acetate up-regulates the transcription of MUC2 intestinal mucin via Ras, ERK, and NF-kappa B.
• Stent-graft placement in a traumatic internal carotid-internal jugular fistula and pseudoaneurysm.
• Stereotactic aspiration of intracerebral haematoma: significance of surgical timing and haematoma volume reduction.
• Study of the aging perception.
• The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42.