Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism.

Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Research Abstract Details 

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Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Abstract Text:

Juan J Jimenez,Jose L Iribarren,

BACKGROUND: Cytokine-mediated inflammation and coagulopathy may occur after cardiac surgery. In this study we investigated the temporal pattern of plasminogen activator inhibitor-1 (PAI-1) gene expression after cardiac surgery and its relation with PAI genotype, and obtained preliminary data regarding its relation to perioperative morbidity. METHODS: The relative change in PAI-1 mRNA 1, 6, and 24 h after cardiopulmonary bypass (CPB) was measured from mononuclear cells in 82 patients undergoing elective cardiac surgery. DNA was analyzed for carriage of the 4G/5G PAI-1 polymorphism. RESULTS: PAI-1 gene expression decreased after CPB in all patients. A larger reduction in PAI-1 gene expression was observed in homozygous carriers of the 5G allele. Homozygous carriers of the 5G allele were also more likely to receive transfusion of coagulation blood products. There was no relation between change in PAI-1 gene expression and duration of CPB. CONCLUSIONS: PAI-1 gene expression decreased over time after CPB. We found a link between PAI-1 genotype, PAI gene expression, and transfusion of coagulation products after cardiac surgery.

Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Publishing Authors By Initials

JJ Jimenez,JL Iribarren,

For similar pathological conditions, signs and symptoms: pathologic processes: postoperative complications research abstracts see: pathological conditions, signs and symptoms: pathologic processes: postoperative complications research

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Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Anesthesia and analgesia

VOLUME: 104

Page Numbers: 1343-7, table of contents

Journal Abbreviation: Anesth. Analg.

ISSN: 1526-7598

DAY: 3

MONTH: Jun

YEAR: 2007

Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Information

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LANGUAGE: eng

NlmUniqueID: 1310650

Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Keywords Mesh Terms:

KEYWORDS: Postoperative Complications

MESH TERMS: etiology

Chemical & Substance for Abstract: Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Information

Substance Name: Plasminogen Activator Inhibitor 1

Registry Number: 0

Grant and Affiliation Information for Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism.

AFFILIATION: Department of Anaesthesia, Trinity Centre for Health Sciences, St. James's Hospital, Dublin, Ireland.

Country: United States

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MEDLINETA: Anesth Analg

REFSOURCE: Anesth Analg. 2007 Nov;105(5):1514; auth

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