Coagulation and fibrinolysis in chronic venous insufficiency.

Coagulation and fibrinolysis in chronic venous insufficiency. Research Abstract Details 

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Coagulation and fibrinolysis in chronic venous insufficiency. Abstract Text:

L Blomgren,G Johansson,A Siegbahn,D Bergqvist,

BACKGROUND: Varicose veins (VV) are common, but only some patients will develop chronic venous insufficiency (CVI) with skin changes or venous ulcer. The pathophysiology of venous ulcer development is complex, and may involve abnormalities in coagulation, fibrinolysis and proinflammatory cytokines. The purpose of this study was to correlate plasma markers within these systems and skin pathology. METHOD: A group of twenty consecutive patients with active or recent venous ulcer were matched for sex and age with further three groups of individuals i.e. controls and patients with VV with and without skin changes respectively. Blood samples were analysed for hemoglobin (HB), total platelet count (TPC), C-reactive protein (CRP), activated partial thromboplastin time (APTT), prothrombin complex (PT), fibrinogen, interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha), D-dimer, tissue plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), prothrombin fragments 1 and 2 (F1 + 2), and thrombin antithrombin III complex (TAT). RESULTS AND CONCLUSION: There was an increase of systemic levels of PAI-1 activity and tPA with progressive skin pathology in patients with CVI, and in the group with active ulcer there was an elevation of F1 + 2. Those findings could reflect a defect fibrinolysis, a thrombotic potential or a damaged endothelium.

Coagulation and fibrinolysis in chronic venous insufficiency. Publishing Authors By Initials

L Blomgren,G Johansson,A Siegbahn,D Bergqvist,

For similar cardiovascular diseases: vascular diseases: venous insufficiency research abstracts see: cardiovascular diseases: vascular diseases: venous insufficiency research

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Coagulation and fibrinolysis in chronic venous insufficiency. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: VASA. Zeitschrift für Gefässkrankheiten. Journal f

VOLUME: 30

Page Numbers: 184-7

Journal Abbreviation: VASA

ISSN: 0301-1526

DAY: 13

MONTH: Jul

YEAR: 2001

Coagulation and fibrinolysis in chronic venous insufficiency. Information

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LANGUAGE: eng

NlmUniqueID: 317051

Coagulation and fibrinolysis in chronic venous insufficiency. Keywords Mesh Terms:

KEYWORDS: Venous Insufficiency

MESH TERMS: blood

Chemical & Substance for Abstract: Coagulation and fibrinolysis in chronic venous insufficiency. Information

Substance Name: Blood Coagulation Factors

Registry Number: 0

Grant and Affiliation Information for Coagulation and fibrinolysis in chronic venous insufficiency.

AFFILIATION: Department of Surgery, St Görans Hospital, Stockholm, Sweden. lena@blomgren@stgoran.se

Country: Switzerland

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MEDLINETA: Vasa

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