Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Research Abstract Details 

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Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Abstract Text:

Seunghee Lee,Dong-Kee Lee,Yali Dou,Jeongkyung Lee,Bora Lee,Eunyee Kwak,Young-Yun Kong,Soo-Kyung Lee,Robert G Roeder,Jae W Lee,

Activating signal cointegrator-2 (ASC-2), a coactivator of multiple transcription factors that include retinoic acid receptor (RAR), associates with histone H3-K4 methyltranferases (H3K4MTs) MLL3 and MLL4 in mixed-lineage leukemia. Here, we show that mice expressing a SET domain mutant of MLL3 share phenotypes with isogenic ASC2+/- mice and that expression and H3-K4 trimethylation of RAR target gene RAR-beta2 are impaired in ASC-2-null mouse embryo fibroblasts (MEFs) or in MEFs expressing siRNAs against both MLL3 and MLL4. We also show that MLL3 and MLL4 are found in distinct ASC-2-containing complexes rather than in a common ASC-2 complex, and they are recruited to RAR-beta2 by ASC-2. In contrast, RAR-beta2 expression is intact in MEFs devoid of menin, a component of MLL1 and MLL2 H3K4MT complexes. These results suggest that ASC-2 confers target gene specificity to MLL3 and MLL4 H3K4MT complexes and that recruitment of H3K4MTs to their target genes generally involves interactions between integral components of H3K4MT complexes and transcription factors.

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Publishing Authors By Initials

S Lee,DK Lee,Y Dou,J Lee,B Lee,E Kwak,YY Kong,SK Lee,RG Roeder,JW Lee,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 103

Page Numbers: 15392-7

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 4

MONTH: 10

YEAR: 2006

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Information

Substance Name: MLL4 protein, mouse

Registry Number: EC 2.1.1.43

Grant and Affiliation Information for Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

AFFILIATION: Deparment of Molecular and Cellular Biology, Division of Diabetes, Endocrinology, and Metabolism, and Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK071900

ACRONYM: DK

MEDLINETA: Proc Natl Acad Sci U S A

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