Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn).

Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn). Research Abstract Details 

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Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn). Abstract Text:

Suk Namgoong,Kelly Sheppard,R Lynn Sherrer,Dieter ,

The important identity elements in tRNA(Gln) and tRNA(Asn) for bacterial GatCAB and in tRNA(Gln) for archaeal GatDE are the D-loop and the first base pair of the acceptor stem. Here we show that Methanothermobacter thermautotrophicus GatCAB, the archaeal enzyme, is different as it discriminates Asp-tRNA(Asp) and Asp-tRNA(Asn) by use of U49, the D-loop and to a lesser extent the variable loop. Since archaea possess the tRNA(Gln)-specific amidotransferase GatDE, the archaeal GatCAB enzyme evolved to recognize different elements in tRNA(Asn) than those recognized by GatDE or by the bacterial GatCAB enzyme in their tRNA substrates.

Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn). Publishing Authors By Initials

S Namgoong,K Sheppard,RL Sherrer,D ,

For similar enzymes and coenzymes: enzymes: transferases: nitrogenous group transferases: transaminases research abstracts see: enzymes and coenzymes: enzymes: transferases: nitrogenous group transferases: transaminases research

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Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn). Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: FEBS letters

VOLUME: 581

Page Numbers: 309-14

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 2

MONTH: 01

YEAR: 2007

Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 155157

Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn). Keywords Mesh Terms:

KEYWORDS: Transaminases

MESH TERMS: chemistry

Chemical & Substance for Abstract: Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn). Information

Substance Name: Transaminases

Registry Number: EC 2.6.1.-

Grant and Affiliation Information for Co-evolution of the archaeal tRNA-dependent amidotransferase GatCAB with tRNA(Asn).

AFFILIATION: Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520 8114, USA.

Country: Netherlands

AGENCY: United States NIGMS

GRANT: R01 GM022854-31

ACRONYM: GM

MEDLINETA: FEBS Lett

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