Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA.

Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA. Research Abstract Details 

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Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA. Abstract Text:

Structural studies are essential to understand mechanisms of non-sequence-specific DNA binding used by chromosomal proteins. A non-histone high-mobility group (HMG) chromosomal protein from Drosophila melanogaster, HMG-D, binds duplex DNA in a non-sequence-specific fashion. The DNA-binding domain of HMG-D has been co-crystallized with a duplex DNA fragment in the primitive orthorhombic space group P2(1)2(1)2(1), with unit-cell dimensions a = 43.74, b = 53.80, c = 86.84 A. Data have been collected to 2.20 A at 99 K, with diffraction observed to at least 2.0 A. Heavy-atom derivative crystals have been obtained by co-crystallization with oligonucleotides halogenated at major-groove positions near the end of the DNA.

Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA. Publishing Authors By Initials

For similar proteins: insect proteins research abstracts see: proteins: insect proteins research

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Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Acta crystallographica. Section D, Biological crys

VOLUME: 55

Page Numbers: 1594-7

Journal Abbreviation: Acta Crystallogr. D Biol. Crys

ISSN: 0907-4449

DAY: 13

MONTH: Sep

YEAR: 1999

Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9305878

Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA. Keywords Mesh Terms:

KEYWORDS: Insect Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Co-crystallization and preliminary crystallographic analysis of the high mobility group domain of HMG-D bound to DNA.

AFFILIATION: Department of Pharmacology, The University of Colorado Health Sciences Center, 4200 E. Ninth Avenue, Denver, CO 80262 USA.

Country: DENMARK

AGENCY: United States NIGMS

GRANT: R01 GM059456-05

ACRONYM: GM

MEDLINETA: Acta Crystallogr D Biol Crysta

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