CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo.

CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Research Abstract Details 

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CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Abstract Text:

Jason F Talbott,Qilin Cao,James Bertram,Michael Nkansah,Richard L Benton,Erin Lavik,Scott R Whittemore,

Delivery of factors capable of promoting oligodendrocyte precursor cell (OPC) survival and differentiation in vivo is an important therapeutic strategy for a variety of pathologies in which demyelination is a component, including multiple sclerosis and spinal cord injury. Ciliary neurotrophic factor (CNTF) is a neuropoietic cytokine that promotes both survival and maturation of a variety of neuronal and glial cell populations, including oligodendrocytes. Present results suggest that, although CNTF has a potent survival and differentiation promoting effect in vitro on OPCs isolated from the adult spinal cord, CNTF administration in vivo is not sufficient to promote oligodendrocyte remyelination in the glial-depleted environment of unilateral ethidium bromide (EB) lesions.

CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Publishing Authors By Initials

JF Talbott,Q Cao,J Bertram,M Nkansah,RL Benton,E Lavik,SR Whittemore,

For similar cells: stem cells research abstracts see: cells: stem cells research

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CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental neurology

VOLUME: 204

Page Numbers: 485-9

Journal Abbreviation: Exp. Neurol.

ISSN: 0014-4886

DAY: 20

MONTH: 12

YEAR: 2006

CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 370712

CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Keywords Mesh Terms:

KEYWORDS: Stem Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Information

Substance Name: Ethidium

Registry Number: 3546-21-2

Grant and Affiliation Information for CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo.

AFFILIATION: MD/PhD Program, University of Louisville, Louisville, KY 40292, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR15576

ACRONYM: RR

MEDLINETA: Exp Neurol

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