Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats.

Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats. Research Abstract Details 

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Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats. Abstract Text:

Stephen C Fowler,Jonathan W Pinkston,Elena Vorontsova,

RATIONALE: Clozapine is an efficacious, symptom-ameliorating, atypical antipsychotic drug with few extrapyramidal side effects. Clozapine has been reported either not to affect or to increase d-amphetamine-induced stereotypy, a behavior that is blocked by typical antipsychotic drugs. OBJECTIVES: This work used a high-resolution measurement system to reassess clozapine's effects on d-amphetamine-induced focused stereotypy (FS) in rats. MATERIALS AND METHODS: A force-plate actometer permitted the quantitation of the rhythm and vigor of movements during FS. Eight rats received a sensitizing series of doses of 5.0 mg/kg d-amphetamine sulfate, and this dosing regimen induced head movements with a rhythm near 10 Hz. Thirty minutes after d-amphetamine treatment, rats received acute clozapine (2.5-10.0 mg/kg), followed by eight, daily clozapine injections (5.0 mg/kg) given with d-amphetamine on days 2, 5, and 8. Effects of acute doses of the alpha1-noradrenergic antagonist prazosin (0.5-2.0 mg/kg) on the d-amphetamine response were also examined. RESULTS: Clozapine dose-dependently slowed the near 10-Hz rhythm and reduced the vigor of the d-amphetamine-induced FS. Clozapine significantly lengthened the duration of the FS phase, but the rhythm remained slowed. No evidence for tolerance to clozapine's rhythm-slowing effects was seen in the subchronic phase. Prazosin dose-dependently reduced the near 10-Hz rhythm induced by d-amphetamine, but prazosin did not lengthen the FS phase. CONCLUSIONS: The results show that clozapine diminished the rhythm and vigor of d-amphetamine-induced stereotyped head movements but, at the same time, lengthened the duration of the expression of the stereotypy. alpha1 antagonism is a likely contributor to the rhythm-modulating effects of clozapine.

Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats. Publishing Authors By Initials

SC Fowler,JW Pinkston,E Vorontsova,

For similar behavior and behavior mechanisms: behavior: stereotyped behavior research abstracts see: behavior and behavior mechanisms: behavior: stereotyped behavior research

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Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Psychopharmacology

VOLUME: 192

Page Numbers: 219-30

Journal Abbreviation:

ISSN: 0033-3158

DAY: 6

MONTH: 02

YEAR: 2007

Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7608025

Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats. Keywords Mesh Terms:

KEYWORDS: Stereotyped Behavior

MESH TERMS: drug effects

Chemical & Substance for Abstract: Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats. Information

Substance Name: Clozapine

Registry Number: 5786-21-0

Grant and Affiliation Information for Clozapine and prazosin slow the rhythm of head movements during focused stereotypy induced by d-amphetamine in rats.

AFFILIATION: Department of Pharmacology and Toxicology, University of Kansas, Lawrence, KS 66045-2505, USA. scfowler@ku.edu

Country: Germany

AGENCY: United States NIMH

GRANT: MH43429

ACRONYM: MH

MEDLINETA: Psychopharmacology (Berl)

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