Cloning of the LH/CG receptor implications for a unique G-protein coupled receptor.

Cloning of the LH/CG receptor implications for a unique G-protein coupled receptor. Research Abstract Details 

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Cloning of the LH/CG receptor implications for a unique G-protein coupled receptor. Abstract Text:

The proteins encoded by the rat and porcine luteinizing hormone (LH)lchorionic gonadotropin (CG) receptor cDNAs appear to be unique members of the G -protein-coupled receptor family. Although they have the characteristic seven transmembrane domains, the LH/CG receptors have relatively low homology to other members o f this family, do not have a G-protein-coupling domain corresponding to that of the a-adrenergic receptor, and contain an unusual long extracellular domain. Experience in the molecular dissection of this receptor family will help guide investigation of the LHICG receptor's functional domains. Further studies are needed to clarify the origin and significance of the various mRNA species hybridizing on Northern blot analyses. Finally, the rat and porcine receptor cDNAs should permit cloning of the human LH/CG receptor, as well as cloning of the thyroid-stimulating hormone and follicle-stimulating hormone receptors.

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MEDLINE DATE: 1990 Mar-Apr

Cloning of the LH/CG receptor implications for a unique G-protein coupled receptor. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Trends in endocrinology and metabolism: TEM

VOLUME: 1

Page Numbers: 181-4

Journal Abbreviation: Trends Endocrinol. Metab.

ISSN: 1043-2760

DAY: 15

MONTH: 04

YEAR: 2008

Cloning of the LH/CG receptor implications for a unique G-protein coupled receptor. Information

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LANGUAGE: eng

NlmUniqueID: 9001516

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Grant and Affiliation Information for Cloning of the LH/CG receptor implications for a unique G-protein coupled receptor.

AFFILIATION: Pediatric Endocrine Unit Department of Pediatrics University of California at San Francisco San Francisco, CA 94143, USA.

Country: United States

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MEDLINETA: Trends Endocrinol Metab

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