Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor.

Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor. Research Abstract Details 

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Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor. Abstract Text:

Ping Li,Sitar Shah,Luoxiu Huang,Aprell L Carr,Yan Gao,Christine Thisse,Bernard Thisse,Lei Li,

Dopamine plays important roles in the regulation of central nervous system (CNS) development and functions. In vertebrates, two families of dopamine receptors, collectively known as dopamine D1 and D2 receptors, have been identified. Recently, dopamine receptors have been targeted by pharmacological and therapeutic studies of neurological disorders, such as Parkinson's disease. Here, we report a study on the molecular characterization of dopamine D1 receptor in zebrafish (Danio rerio). We cloned the full-length cDNA of a zebrafish dopamine D1 receptor, designated as drd1. The sequence of drd1 shares high homology to the sequences of dopamine D1 receptors in mammalian, amphibian, and other fish species. drd1 is expressed in the CNS. The first drd1 expression was observed at approximately 30 hours postfertilization, at which time the expression was seen in the developing diencephalon and hindbrain. In developing retinas, the expression of drd1 was detected in the inner nuclear layer with the exception of the marginal zones. In adult retinas, drd1 expression was detected in most cell types in the inner and outer nuclear layers as well as ganglion cell layer. Differential expression of drd1 in developing and adult retinas may play various roles in regulating visual system functions.

Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor. Publishing Authors By Initials

P Li,S Shah,L Huang,AL Carr,Y Gao,C Thisse,B Thisse,L Li,

For similar proteins: fish proteins: zebrafish proteins research abstracts see: proteins: fish proteins: zebrafish proteins research

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Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 1339-46

Journal Abbreviation:

ISSN: 1058-8388

DAY: 3

MONTH: May

YEAR: 2007

Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor. Keywords Mesh Terms:

KEYWORDS: Zebrafish Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor. Information

Substance Name: Zebrafish Proteins

Registry Number: 0

Grant and Affiliation Information for Cloning and spatial and temporal expression of the zebrafish dopamine D1 receptor.

AFFILIATION: Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.

Country: United States

AGENCY: United States NEI

GRANT: R01 EY15402

ACRONYM: EY

MEDLINETA: Dev Dyn

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