Cloning and expression of a novel armadillo motif containing gene in Xenopus.

Cloning and expression of a novel armadillo motif containing gene in Xenopus. Research Abstract Details 

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Cloning and expression of a novel armadillo motif containing gene in Xenopus. Abstract Text:

Jae-Young Chang,Jin-Kwan Han,

We report an isolation of a cDNA containing armadillo motif (XAMP: Xenopus armadillo motif protein) and its expression during Xenopus development. The open reading frame of Xamp encodes a predicted protein of 275 amino acids including an armadillo motif, and a bipartite nuclear localization signal. Xamp shares significant homology with a putative mouse protein (GeneBank AK009402) in the database. It is expressed both maternally and zygotically. Xamp is localized to the animal region of an egg and in the ectoderm of a gastrula stage embryo. At the neurula stages, Xamp is expressed in the dorsal region of neural tube from which presumptive sensory neurons arise. In addition to its neural tissue specific expression, Xamp transcripts are found to be localized in the developing gut tube. At the early tadpole stage, Xamp is expressed predominantly in the pharyngeal endoderm. As further development proceeds, its expression domain expands to include the entire foregut region but excludes the midgut and hindgut regions. This polarized pattern of expression persists until stage 46 after which, anterior specific expression of Xamp sharply decreases. These results suggest that Xamp may have a role in the neural tissue specification and gut endoderm patterning during the Xenopus development.

Cloning and expression of a novel armadillo motif containing gene in Xenopus. Publishing Authors By Initials

JY Chang,JK Han,

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Cloning and expression of a novel armadillo motif containing gene in Xenopus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Mechanisms of development

VOLUME: 119 Suppl 1

Page Numbers: S83-5

Journal Abbreviation: Mech. Dev.

ISSN: 0925-4773

DAY: 30

MONTH: Dec

YEAR: 2002

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LANGUAGE: eng

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Grant and Affiliation Information for Cloning and expression of a novel armadillo motif containing gene in Xenopus.

AFFILIATION: Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Kyungbuk, 790-784, South Korea.

Country: Ireland

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MEDLINETA: Mech Dev

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