Cloning and characterizing of the ovine MX1 gene promoter/enhancer region.

Cloning and characterizing of the ovine MX1 gene promoter/enhancer region. Research Abstract Details 

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Cloning and characterizing of the ovine MX1 gene promoter/enhancer region. Abstract Text:

A M Assiri,T L Ott,

Ovine MX1 (MX1) is expressed in the uterus during the estrous cycle and is strongly up-regulated during early pregnancy in the uterus and peripheral blood leukocytes. In this study we cloned the MX1 gene promoter/enhancer, and tested its response to interferon tau (IFN-tau). To address the role of IFN tau in regulating MX1 expression, serial deletion mutants were prepared along with a clone that contained a full-length promoter including the two proximal ISREs but lacking an intronic ISRE site. Promoter deletions showed the two proximal ISRE sites, but not the intronic ISRE site, were required for maximal response to IFN tau. Interestingly, MX1 promoter deletion mutants revealed the presence of distal positive (-920 to -715) and negative (-715 to -437) regulatory regions. Identifying positive and negative regulatory regions in MX1 promoter will help define the complex regulation of MX1 during early pregnancy in ruminants.

Cloning and characterizing of the ovine MX1 gene promoter/enhancer region. Publishing Authors By Initials

AM Assiri,TL Ott,

For similar animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep: sheep, domestic research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: ruminants: sheep: sheep, domestic research

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MEDLINE DATE:

Cloning and characterizing of the ovine MX1 gene promoter/enhancer region. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Developmental and comparative immunology

VOLUME: 31

Page Numbers: 847-57

Journal Abbreviation:

ISSN: 0145-305X

DAY: 16

MONTH: 01

YEAR: 2007

Cloning and characterizing of the ovine MX1 gene promoter/enhancer region. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7708205

Cloning and characterizing of the ovine MX1 gene promoter/enhancer region. Keywords Mesh Terms:

KEYWORDS: Sheep, Domestic

MESH TERMS: immunology

Chemical & Substance for Abstract: Cloning and characterizing of the ovine MX1 gene promoter/enhancer region. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Cloning and characterizing of the ovine MX1 gene promoter/enhancer region.

AFFILIATION: Department of Animal Science, Washington State University, Pullman, Washington, USA.

Country: United States

AGENCY: United States NCRR

GRANT: P20-RR15587-01

ACRONYM: RR

MEDLINETA: Dev Comp Immunol

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