Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys.

Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys. Research Abstract Details 

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Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys. Abstract Text:

Su-qing Chen,Hai-feng Zhai,Yan-ying Cui,Jie Shi,Bernard Le Foll,Lin Lu,

AIM: Clonidine is an alpha2 adrenoceptor agonist that is frequently used to reduce withdrawal symptoms during opioid detoxification in humans. The long-term effects of clonidine on withdrawal symptoms and its effects on subsequent drug exposure have not been thoroughly documented. The aim of the study was to determine if clonidine administered during morphine withdrawal in rhesus monkeys produces long-lasting effects on withdrawal symptoms and alters the effects of subsequently taken drugs of abuse. METHODS: Adult male rhesus monkeys were treated with increasing doses of morphine for 90 d to induce opiate (narcotic) dependence. The immediate and long-lasting effects of 1 week's administration of clonidine were measured via the recording of morphine withdrawal signs and the subsequent effects of challenge injections of morphine or cocaine. RESULTS: Monkeys chronically treated with morphine displayed withdrawal signs that lasted 2 weeks after cessation of morphine administration and displayed sensitized responses to subsequent morphine and cocaine injections. Clonidine significantly reduced certain morphine withdrawal signs and overall withdrawal score, but these effects did not persist upon cessation of clonidine treatment. Sensitization to the effects of morphine and cocaine were significantly reduced in monkeys previously treated with clonidine. CONCLUSION: Our results suggest that in addition to its short-term alleviating effect on morphine withdrawal signs, clonidine may reduce subsequent effects of drugs of abuse after prolonged abstinence.

Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys. Publishing Authors By Initials

SQ Chen,HF Zhai,YY Cui,J Shi,B Le Foll,L Lu,

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Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta pharmacologica Sinica

VOLUME: 28

Page Numbers: 473-83

Journal Abbreviation: Acta Pharmacol. Sin.

ISSN: 1671-4083

DAY: 22

MONTH: Apr

YEAR: 2007

Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Clonidine attenuates morphine withdrawal and subsequent drug sensitization in rhesus monkeys.

AFFILIATION: Departments of Neuropharmacology and Clinical Pharmacology, National Institute on Drug Dependence, Peking University, Beijing 100083, China.

Country: China

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MEDLINETA: Acta Pharmacol Sin

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