Clonal Characterization of Sporadic Cribriform-Morular Variant of Papillary Thyroid Carcinoma by Laser Microdissection-Based APC Mutation Analysis.

Clonal Characterization of Sporadic Cribriform-Morular Variant of Papillary Thyroid Carcinoma by Laser Microdissection-Based APC Mutation Analysis. Research Abstract Details 

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Clonal Characterization of Sporadic Cribriform-Morular Variant of Papillary Thyroid Carcinoma by Laser Microdissection-Based APC Mutation Analysis. Abstract Text:

Manish Mani Subramaniam,Thomas Choudary Putti,Diyanah Anuar,Pei Yi Chong,Nilesh Shah,Manuel Salto-Tellez,Richie Soong,Manish Mani Subramaniam,Thomas Choudary Putti,Diyanah Anuar,Pei Yi Chong,Nilesh Shah,Manuel Salto-Tellez,Richie Soong,Manish Mani Subramaniam,Thomas Choudary Putti,Diyanah Anuar,Pei Yi Chong,Nilesh Shah,Manuel Salto-Tellez,Richie Soong,

Cribriform-morular variant (C-MV) of papillary thyroid carcinoma (PTC) is a rare and unusual neoplasm composed of multiple histologic components, including cribriform, papillary, solid, tall columnar, and morular patterns. Analyses of gross C-MV of PTC lesions has linked adenomatous polyposis coli (APC) mutations to its pathogenesis; however, the extent of involvement of mutations in the development of individual components is unclear. We report on bidirectional sequencing of the mutation cluster region (codons 1032-1565) of the APC gene in individually laser-microdissected components of a previously unreported C-MV of PTC. A silent Thr1493Thr gene variant was found in all tumoral components, whereas a 5-base-pair frameshift deletion at codon 1309 was identified only in the morules. Neither variant was observed in matched normal thyroid tissue. These results show the histologic components of C-MV of PTC to have some common mutational background, although additional somatic mutations may be involved in the development of morular structures.

Clonal Characterization of Sporadic Cribriform-Morular Variant of Papillary Thyroid Carcinoma by Laser Microdissection-Based APC Mutation Analysis. Publishing Authors By Initials

MM Subramaniam,TC Putti,D Anuar,PY Chong,N Shah,M Salto-Tellez,R Soong,MM Subramaniam,TC Putti,D Anuar,PY Chong,N Shah,M Salto-Tellez,R Soong,MM Subramaniam,TC Putti,D Anuar,PY Chong,N Shah,M Salto-Tellez,R Soong,

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Clonal Characterization of Sporadic Cribriform-Morular Variant of Papillary Thyroid Carcinoma by Laser Microdissection-Based APC Mutation Analysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of clinical pathology

VOLUME: 128

Page Numbers: 994-1001

Journal Abbreviation: Am. J. Clin. Pathol.

ISSN: 0002-9173

DAY: 20

MONTH: Dec

YEAR: 2007

Clonal Characterization of Sporadic Cribriform-Morular Variant of Papillary Thyroid Carcinoma by Laser Microdissection-Based APC Mutation Analysis. Information

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LANGUAGE: eng

NlmUniqueID: 370470

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AFFILIATION: Oncology Research Institute, Singapore.

Country: United States

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MEDLINETA: Am J Clin Pathol

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