[Clonal analysis of blood cells using X-linked HUMARA gene polymorphism]

[Clonal analysis of blood cells using X-linked HUMARA gene polymorphism] Research Abstract Details 

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[Clonal analysis of blood cells using X-linked HUMARA gene polymorphism] Abstract Text:

K Li,L Wang,Y Hao,H Chao,Q Meng,B Feng,K Tang,S Bian,

OBJECTIVE: To explore the method for clonal analysis of blood cells. METHODS: Thirty female AML patients and 20 normal female subjects were analysed by the analysis of X-linked HUMARA gene polymorphism and methylation pattern. RESULTS: The heterozygote rate of HUMARA gene in Chinese women was 88% and the gene had a stable methylation pattern. Out of 20 control females, 17 were heterozygotes and among them 15 were polyclonal, 2 (11.8%) showed skewed X-inactivation. All heterozygote AML were clonal hematopoiesis. CONCLUSION: HUMARA gene polymorphism is a good marker for clonality analysis of blood cells.

[Clonal analysis of blood cells using X-linked HUMARA gene polymorphism] Publishing Authors By Initials

K Li,L Wang,Y Hao,H Chao,Q Meng,B Feng,K Tang,S Bian,

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[Clonal analysis of blood cells using X-linked HUMARA gene polymorphism] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 18

Page Numbers: 247-50

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 29

MONTH: May

YEAR: 1997

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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