Clivus chordoma: a report of 12 recent cases and review of the literature.

Clivus chordoma: a report of 12 recent cases and review of the literature. Research Abstract Details 

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Clivus chordoma: a report of 12 recent cases and review of the literature. Abstract Text:

J W Harbour,M T Lawton,G R Criscuolo,M J Holliday,D E Mattox,D M Long,

Twelve patients with histologically confirmed clivus chordoma were treated at the Johns Hopkins Hospital between 1971 and 1989. Eight of the patients were men and four were women. The mean age at first operation was 51 years (range, 10 to 80). The most common presenting symptoms were headache, diplopia, dysphagia and dysarthria, and facial sensory changes. Computed tomography, with and without contrast enhancement, proved adequate for tumor identification and localization. Magnetic resonance imaging and angiography were occasionally employed to localize the tumors further and to define tumor vascular supply and proximity to vascular structures. Twenty-two resections were performed in 11 patients, and another patient underwent biopsy only. Seven were also treated with radiation therapy. Tumors recurred in eight patients, six of whom underwent further operations. The mean time to first recurrence was 22 months (range 8 to 36 months). Six of the patients are still alive, with a mean follow-up of 31 months (range, 3 to 89 months) from first surgical resection. The mean survival time from first treatment was 31 months (range, 4 to 62 months) among those patients who died. There was no operative mortality. The 5-year cumulative survival rate was 20%. Six patients with long follow-up have had fair to good results, being free of recurrences for at least a year. However, none of the patients returned to their premorbid baseline of activities. Five of the patients had tumors with the histologic diagnosis of chondroid chordoma. Three of these patients are still alive. The mean age at first treatment was 44 (compared with 62 for typical chordomas). The mean time from symptoms to diagnosis was 29 months (typical chordomas, 18 months). The mean length of survival and time to tumor recurrence were not significantly different between chondroid and typical chordomas.

Clivus chordoma: a report of 12 recent cases and review of the literature. Publishing Authors By Initials

JW Harbour,MT Lawton,GR Criscuolo,MJ Holliday,DE Mattox,DM Long,

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Clivus chordoma: a report of 12 recent cases and review of the literature. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Skull base surgery

VOLUME: 1

Page Numbers: 200-6

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ISSN: 1052-1453

DAY: 15

MONTH: 12

YEAR: 1991

Clivus chordoma: a report of 12 recent cases and review of the literature. Information

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LANGUAGE: eng

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Country: United States

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MEDLINETA: Skull Base Surg

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