Clinically significant pharmacokinetic drug interactions between antiepileptic drugs.

Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. Research Abstract Details 

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Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. Abstract Text:

Pharmacokinetic interactions between antiepileptics represent a major potential complication of epilepsy treatment because drug combinations are common. This review discusses pharmacokinetic drug interactions of clinical significance involving antiepileptics and cytochrome P450 (CYP). Most commonly used antiepileptics are eliminated through hepatic metabolism, catalysed by the enzymes CYP2C9, CYP2C19 and CYP3A4 and uridine diphosphate glucuronosyltransferase (UDGPT). Antiepileptics are associated with a wide range of drug interactions, including hepatic enzyme induction and inhibition. Phenytoin, phenobarbiral, primidone and carbamazepine induce CYP and UDPGT enzymes while valproic acid inhibits them. Avoidance of unnecessary polypharmacy, selection of alternative agents with lower interaction potential and careful dosage adjustments based on serum drug concentration monitoring and clinical observation are the main methods for reducing the risks associated with these interactions.

Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. Publishing Authors By Initials

For similar therapeutics: drug therapy: polypharmacy research abstracts see: therapeutics: drug therapy: polypharmacy research

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Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 24

Page Numbers: 87-92

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Apr

YEAR: 1999

Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. Information

Number of References: 51

LANGUAGE: eng

NlmUniqueID: 8704308

Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. Keywords Mesh Terms:

KEYWORDS: Polypharmacy

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Clinically significant pharmacokinetic drug interactions between antiepileptic drugs. Information

Substance Name: Cytochrome P-450 Enzyme System

Registry Number: 9035-51-2

Grant and Affiliation Information for Clinically significant pharmacokinetic drug interactions between antiepileptic drugs.

AFFILIATION: Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan. einosuke@md.tsukuba.ac.jp

Country: ENGLAND

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MEDLINETA: J Clin Pharm Ther

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