Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF.

Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF. Abstract Text:

John G F Cleland,Alison P Coletta,Ahmed Tageldien Abdellah,Klaus K Witte,Neil Hobson,Andrew L Clark,

This article provides information and a commentary on trials relevant to the pathophysiology, prevention and treatment of heart failure, presented at Heart Rhythm 2007 organised by the Heart Rhythm Society which was held in Denver, USA and Heart Failure 2007 organised by the Heart Failure Association of the European Society of Cardiology which was held in Hamburg, Germany. Unpublished reports should be considered as preliminary data, as analyses may change in the final publication. The CARISMA study suggests that non-invasive screening tests may help to identify post-MI patients who may benefit from ICD therapy. Data from the PREPARE study show that more conservative ICD programming can reduce morbidity at the cost of an increased risk of arrhythmic syncope. DAVID II indicates that atrial pacing may be a safe alternative to ventricular back-up pacing in patients with left ventricular dysfunction and standard indications for an ICD. The incidence of persistent atrial fibrillation in patients with sinus node disease in SAVE-PACE was reduced by dual chamber minimal ventricular pacing compared to conventional dual chamber pacing. The pilot phase of the PROTECT studies confirmed 30 mg as the dose of the selective A1 adenosine receptor antagonist KW-3902 to be used in pivotal studies. AREA-IN-CHF failed to show a beneficial effect of canrenone on LV volumes compared to placebo however some beneficial effects on secondary clinical endpoints were observed.

Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF. Publishing Authors By Initials

JG Cleland,AP Coletta,AT Abdellah,KK Witte,N Hobson,AL Clark,

For similar heterocyclic compounds: alkaloids: xanthines research abstracts see: heterocyclic compounds: alkaloids: xanthines research

PUBMED ID PMID:

MEDLINE DATE:

Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF. Journal Published:

PUBLICATION TYPE: Randomized Controlled Trial

Journal: European journal of heart failure : journal of the

VOLUME: 9

Page Numbers: 850-3

Journal Abbreviation: Eur. J. Heart Fail.

ISSN: 1388-9842

DAY: 17

MONTH: 07

YEAR: 2007

Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100887595

Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF. Keywords Mesh Terms:

KEYWORDS: Xanthines

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF. Information

Substance Name: Canrenone

Registry Number: 976-71-6

Grant and Affiliation Information for Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF.

AFFILIATION: Department of Cardiology, University of Hull, Castle Hill Hospital, Cottingham, Kingston-upon-Hull, HU16 5JQ, UK.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Heart Fail

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Clinical trials update from Heart Rhythm 2007 and Heart Failure 2007: CARISMA, PREPARE, DAVID II, SAVE-PACE, PROTECT and AREA-IN-CHF Related Publications

• A comparison of the 'Sheffield' Prognostic Index with forearm muscle dynamometry in patients from Sheffield undergoing major abdominal and urological surgery.
• Abrupt, but not gradual visuomotor distortion facilitates adaptation in children with developmental coordination disorder.
• An evaluation of production and economic efficiency of two beef systems from calving to slaughter.
• Analyzing milestones in smoking cessation: illustration in a nicotine patch trial in adult smokers.
• Best Practices in NCLEX-RN Readiness Preparation for Baccalaureate Student Success.
• Body image evaluations in obese females with binge eating disorder.
• CERR: a computational environment for radiotherapy research.
• Cheese pH, protein concentration, and formation of calcium lactate crystals.
• Clinical Nutrition-A viable entity.
• Contraceptive usage, knowledge and correlates of usage among female emergency department patients.
• Correlates of mammography in a national analysis compared to results in quintile- and regionally-defined samples.
• Cyclic peptide helices: a hybrid beta-hairpin/beta-helical supersecondary structure.
• Deconstructing B cell tolerance to basement membranes.
• Diagnostic imaging for chronic orofacial pain, maxillofacial osseous and soft tissue pathology and temporomandibular disorders.
• Different lengths of times for progressions in adolescent substance involvement.
• Effect of nutrition support on clinical outcome.
• Effects of increased complexity of visuo-motor transformations on children's arm movements.
• Evolution of the class III HD-Zip gene family in land plants.
• Feeding value of pastures for ruminants.
• Genetic variants of the P-glycoprotein gene Abcb1b modulate opioid-induced hyperalgesia, tolerance and dependence.
• Interactive but not direct effects of perceived racism and trait anger predict resting systolic and diastolic blood pressure in black adolescents.
• Liquid chromatographic determination of the pH-dependent degradation of eseroline - hydrolysis product of physostigmine.
• Long term parenteral nutrition in the management of severe Crohn's disease.
• Membrane lipid physiology and toxin catabolism underlie ethanol and acetic acid tolerance in Drosophila melanogaster.
• Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker.
• Parent-of-origin effects on mRNA expression in Drosophila melanogaster not caused by genomic imprinting.
• Preliminary evidence for an association between social anxiety symptoms and avoidance of negative faces in school-age children.
• Priapism - A complication of home parenteral nutrition?
• RASSF Family Proteins and Ras Transformation.
• Undernutrition in elective colorectal surgery. Implications for post operative morbidity.