Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries.

Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. Abstract Text:

Deepak Dewan,Sanjeev Gulati,Raj K Sharma,Narayan Prasad,Manoj Jain,Amit Gupta,Alok Kumar,

Crescentic glomerulonephritis (CsGN) is an uncommon entity in children. This prospective study was conducted to evaluate the aetiology, clinical spectrum and outcome in children with crescentic glomerulonephritis. The single-centre prospective study comprised of 22 children with biopsy proven CsGN who had been referred to our institute over the period January 2000 to December 2005. These patients were subjected to detailed clinical and biochemical examinations. The diagnosis of underlying renal disease was based on various criteria, including the clinical picture, serology and histopathology. The patients received intravenous methyl prednisolone, oral steroid treatment, and oral cyclophosphamide with or without plasmapheresis. All patients received supportive care, including control of hypertension and oedema and supportive management of renal insufficiency. During this 5-year period, CsGN accounted for 5.1% of all biopsies done in children. The mean age was 12.27 years (range 4 years to 18 years). There were eight girls and 14 boys. The mean duration of symptoms prior to referral was 2.47 months (range 5 days to 21 months). Aetiology was immune complex in 19 cases, anti-glomerular basement membrane (anti-GBM) antibody disease in two cases and pauci-immune (Wegener's granulomatosis) in one case. The percentage of crescents ranged from 50% to 100% (mean 70.6%). Twenty-one out of 22 (95.5%) children in our series had hypertension at presentation that required treatment with antihypertensive medications. The serum creatinine level at presentation ranged from 1.5 mg/dl to 11.4 mg/dl (mean 5.5 mg/dl). Of the 22 children, two were lost to follow-up, while the mean follow-up period of the rest of the 20 children was 8.13 months (range 1 month to 43 months). At the last follow-up of the 22 children, ten had stage 5 chronic kidney disease (CKD) and three had stage 4 CKD, while seven children had a calculated glomerular filtration rate (GFR) of >60 ml/min per 1.73 m(2) body surface area. Persistent proteinuria was seen on follow-up in the majority [13/20 (65%)] of patients. The outcome of CsGN in children continues to be poor, in our experience, due to delayed referral and delayed diagnosis. This was correlated histologically by the presence of fibrocellular crescents in the majority of our patient. Thus CsGN should be treated as a renal emergency. A greater awareness of this disease needs to be created amongst the referring paediatricians in developing countries to facilitate early diagnosis and prompt treatment.

Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. Publishing Authors By Initials

D Dewan,S Gulati,RK Sharma,N Prasad,M Jain,A Gupta,A Kumar,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric nephrology (Berlin, Germany)

VOLUME: 23

Page Numbers: 389-94

Journal Abbreviation: Pediatr. Nephrol.

ISSN: 0931-041X

DAY: 11

MONTH: 12

YEAR: 2007

Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8708728

Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries.

AFFILIATION: Department of Nephrology, Sanjay Gandhi Post-Graduate Institute of Medical Sciences, Rae Bareily Road, Lucknow, 226014, India, sgulatipedneph@yahoo.com.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pediatr Nephrol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Clinical spectrum and outcome of crescentic glomerulonephritis in children in developing countries Related Publications

• A modified Plasmodium falciparum growth inhibition assay (GIA) to assess activity of plasma from malaria endemic areas.
• A new paradigm for the treatment of high-risk prostate cancer: radiosensitization with docetaxel.
• An inherent role of microtubule network in the action of nuclear receptor.
• Antibody responses to Plasmodium falciparum vaccine candidate antigens in three areas distinct with respect to altitude.
• Breast cancer-amplified sequence 3, a target of metastasis-associated protein 1, contributes to tamoxifen resistance in premenopausal patients with breast cancer.
• Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action.
• Cognitive function in adults with type 2 diabetes and major depression.
• Diagnosis and management of extensive vertex birth molding.
• Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes.
• Effect of individual and multiple antioxidant vitamins on growth and morphology of human nontumorigenic and tumorigenic parotid acinar cells in culture.
• Functional analysis of alternative isoforms of the transcription factor PAX3 in melanocytes in vitro.
• HPA axis activity and neuropathogenesis in HIV-1 clade C infection.
• How substance use differs among American secondary schools.
• Influence of Agrobacterium rhizogenes Strains on Biomass and Alkaloid Productivity in Hairy Root Lines of Hyoscyamus muticus and H. albus *.
• Letter to the editor: The suckling-micturition reflex in cows.
• Metal-binding properties of human centrin-2 determined by micro-electrospray ionization mass spectrometry and UV spectroscopy.
• Metastasis tumor antigens, an emerging family of multifaceted master coregulators.
• Metastatic tumor antigen 3 is a direct corepressor of the Wnt4 pathway.
• Modification of the expression of adenosine 3',5'-cyclic monophosphate-induced differentiated functions in neuroblastoma cells by beta-carotene and D-alpha-tocopheryl succinate.
• P21-activated kinases in human cancer.
• Pituitary abscess: Report of four cases and review of literature.
• Potential medicinal plants for CNS disorders: an overview.
• Protein disulfide isomerase assisted protein folding in malaria parasites.
• Quality of life in HIV subtype C infection among asymptomatic subjects and its association with CD4 counts and viral loads--a study from South India.
• Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
• Sexual differentiation and development in the malaria parasite.
• Standard wound coverage techniques for extremity war injury.
• Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia.
• Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV.
• p21-activated kinase signaling in breast cancer.