Clinical significance of neutrophil apoptosis in peripheral blood of patients with type 2 diabetes mellitus.

Clinical significance of neutrophil apoptosis in peripheral blood of patients with type 2 diabetes mellitus. Research Abstract Details 

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Clinical significance of neutrophil apoptosis in peripheral blood of patients with type 2 diabetes mellitus. Abstract Text:

Chiaki Sudo,Hatsue Ogawara,Almaqoul Wedad Hamdi Saleh,Natsumi Nishimoto,Toshihiro Utsugi,Yoshio Ooyama,Yukihito Fukumura,Masami Murakami,Hiroshi Handa,Shoichi Tomono,Hirokazu Murakami,Chiaki Sudo,Hatsue Ogawara,Almaqoul Wedad Hamdi Saleh,Natsumi Nishimoto,Toshihiro Utsugi,Yoshio Ooyama,Yukihito Fukumura,Masami Murakami,Hiroshi Handa,Shoichi Tomono,Hirokazu Murakami,Chiaki Sudo,Hatsue Ogawara,Almaqoul Wedad Hamdi Saleh,Natsumi Nishimoto,Toshihiro Utsugi,Yoshio Ooyama,Yukihito Fukumura,Masami Murakami,Hiroshi Handa,Shoichi Tomono,Hirokazu Murakami,

Although neutrophils are essential components of the natural immune system, they have also been implicated in the pathogenesis of tissue injuries. We assessed the clinical significance of neutrophil apoptosis in the peripheral blood of patients with type 2 diabetes mellitus (T2DM). Patients and Methods: The study included 52 patients with T2DM (30 men, 22 women). Control subjects were 16 healthy volunteers without diabetes (7 men, 9 women). Neutrophil apoptosis levels were measured active caspase-3 positive rate by flow cytometry. Results: The mean rate of neutrophil apoptosis in patients with T2DM was 15.0% (95% confidence interval [CI]: 9.5%~20.5%), while that in the control group was 5.8% (95% CI: 1.6%~10.0%). There were significant negative correlations between neutrophil apoptosis rate and hemoglobin (Hb) A1c levels (r = -0.352, P < .01). The mean rate of neutrophil apoptosis in the patient group with the 3 major complications (diabetic retinopathy, nephropathy, and neuropathy) was 11.1% (95% CI: 5.5%-16.7%, n = 36) and that of another group without complications was 23.8% (95% CI: 11.4%-36.2%, n = 16). There was a significant difference between these 2 groups (P < .05). Conclusions: The neutrophil apoptosis rate in patients with T2DM was significantly correlated with HbA1C levels. The mean rate of neutrophil apoptosis in the patient group with 3 major diabetic complications remained lower than that in another patient group without complications. The inhibition of neutrophil apoptosis by chronic hyperglycemia is thought to promote tissue injury and to enhance the risk of microangiopathy.

Clinical significance of neutrophil apoptosis in peripheral blood of patients with type 2 diabetes mellitus. Publishing Authors By Initials

C Sudo,H Ogawara,AW Saleh,N Nishimoto,T Utsugi,Y Ooyama,Y Fukumura,M Murakami,H Handa,S Tomono,H Murakami,C Sudo,H Ogawara,AW Saleh,N Nishimoto,T Utsugi,Y Ooyama,Y Fukumura,M Murakami,H Handa,S Tomono,H Murakami,C Sudo,H Ogawara,AW Saleh,N Nishimoto,T Utsugi,Y Ooyama,Y Fukumura,M Murakami,H Handa,S Tomono,H Murakami,

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Clinical significance of neutrophil apoptosis in peripheral blood of patients with type 2 diabetes mellitus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Laboratory hematology : official publication of th

VOLUME: 13

Page Numbers: 108-12

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ISSN: 1080-2924

DAY: 6

MONTH: 11

YEAR: 2007

Clinical significance of neutrophil apoptosis in peripheral blood of patients with type 2 diabetes mellitus. Information

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LANGUAGE: eng

NlmUniqueID: 9615688

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AFFILIATION: Department of Laboratory Sciences, Gunma University School of Health Sciences.

Country: United States

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MEDLINETA: Lab Hematol

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