Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia.

Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia. Research Abstract Details 

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Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia. Abstract Text:

Hae Suk Cheong,Cheol-In Kang,Ki Tae Kwon,Sang Tack Heo,Yu Mi Wi,Eun Seok Kim,Jin Seo Lee,Kwan Soo Ko,Doo Ryeon Chung,Nam Yong Lee,Jae-Hoon Song,Kyong Ran Peck,Hae Suk Cheong,Cheol-In Kang,Ki Tae Kwon,Sang Tack Heo,Yu Mi Wi,Eun Seok Kim,Jin Seo Lee,Kwan Soo Ko,Doo Ryeon Chung,Nam Yong Lee,Jae-Hoon Song,Kyong Ran Peck,

Background The increasing antimicrobial resistance of Escherichia coli infection is of great concern, even for community-onset infections. Methods We conducted a retrospective cohort study of patients with E. coli bacteraemia who visited the emergency department of the Samsung Medical Center from February 2002 to December 2005 to identify the risk factors for mortality and association between healthcare-associated (HCA) infection and mortality. We classified community-onset E. coli bacteraemia into community-acquired (CA) and HCA infections. Results A total of 508 patients with E. coli bacteraemia were enrolled (mean age, 61.8 +/- 14.3 years; male/female, 191:317). The HCA E. coli bacteraemia had significantly higher severity of illness and higher antimicrobial resistance rate than CA bacteraemia. The overall 30-day mortality rate was 13.6% (69/508) and the mortality of HCA infections was significantly higher than that of CA infections (26.4% versus 9.6%, P < 0.001). In multivariate analysis, high Charlson's co-morbidity index (OR 4.84, 95% CI 2.14-10.95, P < 0.001), high Pitt bacteraemia score (OR 32.03, 95% CI 13.08-74.43, P < 0.001), presentation with acute renal failure (OR 4.11, 95% CI 1.90-8.89, P < 0.001) and HCA bacteraemia (OR 2.34, 95% CI 1.09-5.01, P = 0.030) were found to be the significant risk factors for 30-day mortality in E. coli bacteraemia. Conclusions The mortality rate of HCA E. coli bacteraemia was higher than twice that of CA bacteraemia and HCA bacteraemia was one of the significant risk factors for mortality, even after adjusting for a large number of potential confounders.

Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia. Publishing Authors By Initials

HS Cheong,CI Kang,KT Kwon,ST Heo,YM Wi,ES Kim,JS Lee,KS Ko,DR Chung,NY Lee,JH Song,KR Peck,HS Cheong,CI Kang,KT Kwon,ST Heo,YM Wi,ES Kim,JS Lee,KS Ko,DR Chung,NY Lee,JH Song,KR Peck,

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Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of antimicrobial chemotherapy

VOLUME: 60

Page Numbers: 1355-60

Journal Abbreviation: J. Antimicrob. Chemother.

ISSN: 0305-7453

DAY: 8

MONTH: 10

YEAR: 2007

Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia. Information

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LANGUAGE: eng

NlmUniqueID: 7513617

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Grant and Affiliation Information for Clinical significance of healthcare-associated infections in community-onset Escherichia coli bacteraemia.

AFFILIATION: Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 ILwon-dong, Gangnam-gu, Seoul 135-710, Republic of Korea.

Country: England

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MEDLINETA: J Antimicrob Chemother

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