Clinical predictors of neurocognitive deficits in children with chronic kidney disease.

Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Research Abstract Details 

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Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Abstract Text:

Jennifer Slickers,Peter Duquette,Stephen Hooper,Debbie Gipson,

The purpose of the study was to explore associations between neurocognitive function and chronic kidney disease (CKD)-related clinical characteristics. Twenty-nine children, ages 7 to 19 years, with an estimated creatinine clearance (eCrCl) of 4-89 ml/min per 1.73 m2 body surface area were enrolled. Intellectual function (IQ), memory, and attention were measured and expressed as age-based standard scores. Clinical data were obtained by physical examination, laboratory testing, parental questionnaires and medical chart review. Pearson correlations and standard Student's t-tests were used to identify significant (P < 0.05) relationships between targeted clinical variables and neurocognitive scores. Increased CKD severity correlated with lower IQ (P = 0.001) and memory function (P = 0.02). Memory function was lower in children with longer duration of disease (P = 0.03). Similarly, IQ scores were lowest when kidney disease had started at a younger age (P = 0.03) and with a greater percent of life with CKD (P = 0.04). Our findings provide preliminary evidence that increased disease severity, longer duration of disease, and younger age of onset of kidney disease potentially place children with CKD at increased risk of neurocognitive deficits. Additional investigation is required to better quantify these risk factors, particularly regarding how much variability is accounted for by these specific risk factors.

Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Publishing Authors By Initials

J Slickers,P Duquette,S Hooper,D Gipson,

For similar therapeutics: renal replacement therapy research abstracts see: therapeutics: renal replacement therapy research

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Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric nephrology (Berlin, Germany)

VOLUME: 22

Page Numbers: 565-72

Journal Abbreviation: Pediatr. Nephrol.

ISSN: 0931-041X

DAY: 16

MONTH: 12

YEAR: 2006

Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Information

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LANGUAGE: eng

NlmUniqueID: 8708728

Clinical predictors of neurocognitive deficits in children with chronic kidney disease. Keywords Mesh Terms:

KEYWORDS: Renal Replacement Therapy

MESH TERMS: diagnosis

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Grant and Affiliation Information for Clinical predictors of neurocognitive deficits in children with chronic kidney disease.

AFFILIATION: UNC Kidney Center, University of North Carolina, 7007D Burnett-Womack CB #7155, Chapel Hill, NC 27599-7155, USA. slickers@unch.unc.edu

Country: Germany

AGENCY: United States NCRR

GRANT: RR00046

ACRONYM: RR

MEDLINETA: Pediatr Nephrol

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