Clinical predictive criteria for response to endocrine treatment and the receptor status.

Clinical predictive criteria for response to endocrine treatment and the receptor status. Research Abstract Details 

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Clinical predictive criteria for response to endocrine treatment and the receptor status. Abstract Text:

H Maass,W Jonat,

Recent data suggest that estrogen receptors are not only useful in predicting the response to endocrine treamtent of advanced breast cancer, but also in predicting the effect of chemotherapy in such cancer (Lippman, 1978). Jensen (1978) and Knight et al (1977) observed that patients with no or very low estrogen-receptor content in their tumors have a shorter disease-free interval. Another important clinical parameter for response to endocrine manipulation is the site of metastases. Patients with visceral metastases, especially of liver and brain, are known to respond poorly to any kind of endocrine therapy. Duration of menopause is another clinical parameter that must be considered. Patients in the 1st 5 years after menopause respond very poorly to ablative and additive endocrine treatments. Women in the early years of menopause have been found to have quantitative ER (estrogen receptor) contents comparable to those of elderly patients. Some patients are not suitable for endocrine treatment only regardless of their positive receptor status; such patients are candidates for a combined hormonal and cytotoxic therapy. If ER (+) patients with unfavorable prognosis are excluded from trials, better correlations in the remaining subjects may be achieved.

Clinical predictive criteria for response to endocrine treatment and the receptor status. Publishing Authors By Initials

H Maass,W Jonat,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: remission, spontaneous research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: remission, spontaneous research

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Clinical predictive criteria for response to endocrine treatment and the receptor status. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 71

Page Numbers: 26-9

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1980

Clinical predictive criteria for response to endocrine treatment and the receptor status. Information

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LANGUAGE: eng

NlmUniqueID: 44671

Clinical predictive criteria for response to endocrine treatment and the receptor status. Keywords Mesh Terms:

KEYWORDS: Remission, Spontaneous

MESH TERMS: analysis

Chemical & Substance for Abstract: Clinical predictive criteria for response to endocrine treatment and the receptor status. Information

Substance Name: Receptors, Estrogen

Registry Number: 0

Grant and Affiliation Information for Clinical predictive criteria for response to endocrine treatment and the receptor status.

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Country: GERMANY, WEST

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MEDLINETA: Recent Results Cancer Res

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