Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women.

Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women. Research Abstract Details 

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Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women. Abstract Text:

T Siddiqui,S Khan,N Kayani,S Pervez,A Salam,

BACKGROUND: Axillary lymph node involvement in primary breast cancer is one of its most important prognostic features. Thus any factors that may predict axillary lymph node involvement in this setting could be potentially helpful in treatment planning and other interventions. OBJECTIVE: The objective of this study was to evaluate clinical, pathological and immuno-histochemical markers in univariate and multivariate analysis, which may be helpful predictors of axillary lymph node involvement in breast cancer. METHOD: A retrospective analysis of 555 cases. Of these 58% had axillary nodal positivity and 42% were negative. CONCLUSION: Factors of no significance included patient's age, height, weight, age of first pregnancy, parity, marital status, menopausal status, family history of breast cancer, side of tumor. In univariate analysis the age of menarche, duration of symptoms, tumor size, site in outer quadrant, S phase and skin and nipple involvement all predicted axillary nodal involvement. The length of breast-feeding, increased intraductal component and increased PCNA were inversely proportional to nodal involvement. In multiple regression analysis however only size of the tumor, involvement of the skin and nipple and disease in the outer quadrant of breast were the factors, which assumed significance.

Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women. Publishing Authors By Initials

T Siddiqui,S Khan,N Kayani,S Pervez,A Salam,

For similar proteins: nuclear proteins: proliferating cell nuclear antigen research abstracts see: proteins: nuclear proteins: proliferating cell nuclear antigen research

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Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: JPMA. The Journal of the Pakistan Medical Associat

VOLUME: 52

Page Numbers: 192-5

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ISSN: 0030-9982

DAY: 12

MONTH: May

YEAR: 2002

Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women. Information

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LANGUAGE: eng

NlmUniqueID: 7501162

Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women. Keywords Mesh Terms:

KEYWORDS: Proliferating Cell Nuclear Antigen

MESH TERMS: analysis

Chemical & Substance for Abstract: Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women. Information

Substance Name: Proliferating Cell Nuclear Antigen

Registry Number: 0

Grant and Affiliation Information for Clinical, pathological and molecular factors predicting axillary node involvement in primary breast cancer in Pakistani women.

AFFILIATION: Department of Medicine, Surgery, Aga Khan University Hospital, Karachi.

Country: Pakistan

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MEDLINETA: J Pak Med Assoc

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