Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study.

Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study. Research Abstract Details 

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Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study. Abstract Text:

Hyun Joo Jang,Jung Han Kim,Hun Ho Song,Kyung Hee Woo,Mi Kim,Sea Hyub Kae,Jin Lee,Ji Wong Cho,Jung Hun Kang,Soon Il Lee,Soo Jung Gong,Jung Ae Lee,Dae Young Zang,Hyun Joo Jang,Jung Han Kim,Hun Ho Song,Kyung Hee Woo,Mi Kim,Sea Hyub Kae,Jin Lee,Ji Wong Cho,Jung Hun Kang,Soon Il Lee,Soo Jung Gong,Jung Ae Lee,Dae Young Zang,

We investigated early postoperative morbidity, mortality, and long-term outcomes in patients with liver cirrhosis (LC) who had undergone curative surgery for gastric cancer. The medical records of patients with LC who had undergone radical gastrectomy for gastric adenocarcinoma between January 1996 and September 2006 were retrospectively reviewed. A total of 57 patients were enrolled in this study. Forty-six patients (81%) were classified into Child's class A. In 22 patients (39%) postoperative complications developed, the most common being ascites (23%), followed by wound infection and hepatic encephalopathy. Postoperative ascites occurred more frequently in patients with Child's class B or C than in those with class A (63.6% vs 13%, P = 0.001). Massive ascites developed in 4 patients, 3 of whom had Child's class B and underwent D2 lymph node (LN) dissection, and 1 of whom had Child's class C and a D1 LN dissection. Postoperative mortality occurred in 5 patients (9%), with a significantly higher mortality rate for patients with Child's class B or C than for those with class A (27.2% vs 4.3%, P = 0.045). With a median follow-up of 32 months, the estimated 5-year survival rate for all patients was 54%. Regardless of the tumor depth, overall survival was longer for patients with Child's class A than for those with Child's class B or C. These results demonstrated that radical gastrectomy with extended LN dissection is feasible in patients with compensated LC. For patients with moderate to severe hepatic dysfunction, however, D1 or less extensive LN dissection may be the more reasonable surgical procedure.

Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study. Publishing Authors By Initials

HJ Jang,JH Kim,HH Song,KH Woo,M Kim,SH Kae,J Lee,JW Cho,JH Kang,SI Lee,SJ Gong,JA Lee,DY Zang,HJ Jang,JH Kim,HH Song,KH Woo,M Kim,SH Kae,J Lee,JW Cho,JH Kang,SI Lee,SJ Gong,JA Lee,DY Zang,

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Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Digestive diseases and sciences

VOLUME: 53

Page Numbers: 399-404

Journal Abbreviation: Dig. Dis. Sci.

ISSN: 0163-2116

DAY: 28

MONTH: 06

YEAR: 2007

Clinical Outcomes of Patients with Liver Cirrhosis Who Underwent Curative Surgery for Gastric Cancer: A Retrospective Multi-center Study. Information

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LANGUAGE: eng

NlmUniqueID: 7902782

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AFFILIATION: Department of Internal Medicine, Kang Nam Sacred-Heart Hospital, Hallym University College of Medicine, 948-1 Daelim -1 Dong, Youngdungpo-Gu, Seoul, South Korea, harricil@hotmail.com.

Country: United States

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MEDLINETA: Dig Dis Sci

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