Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus.

Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus. Research Abstract Details 

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Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus. Abstract Text:

Masaki Akimoto,Kakushi Matsushita,Yukio Suruga,Noriko Aoki,Atsuo Ozaki,Kimiharu Uozumi,Chuwa Tei,Naomichi Arima,

OBJECTIVE: Human T lymphotropic virus type I (HTLV-I) may be associated with some connective tissue autoimmune diseases, including systemic lupus erythematosus (SLE). To determine the relationship between HTLV-I infection and SLE, we examined the clinical manifestations of SLE patients with HTLV-I infection. METHODS: Eighty-nine patients with SLE were screened for antibodies to HTLV-I by electrochemiluminescence immunoassay. The presence of HTLV-I proviral sequences in peripheral blood mononuclear cells (PBMC) was determined by real-time polymerase chain reaction (PCR) quantification and Southern blotting analysis. The differences in clinical manifestations between HTLV-I-seropositive and seronegative patients with SLE were analyzed statistically. RESULTS: Fourteen of 89 (15.7%) patients were HTLV-I seropositive. All PBMC samples from 11 patients tested by PCR and 3 samples from 10 patients tested by Southern blotting analysis were positive for HTLV-I-related sequences. The age of HTLV-I-seropositive patients with SLE was significantly higher than that of seronegative patients (median 60 vs 42 yrs; p < 0.0005). The age at onset of SLE in HTLV-I-seropositive patients was also significantly higher than that of seronegative patients (median 45.5 vs 30 yrs; p <0.0005). The lymphocyte count in HTLV-I-seropositive SLE patients was significantly higher than that of seronegative patients (median 1740 vs 1066/microl; p = 0.027). The maintenance dose of prednisolone in HTLV-I-seropositive patients with SLE was significantly lower than that in seronegative patients (median 5 vs 9 mg/day; p = 0.012). CONCLUSION: This is the first report of the differences in clinical manifestations between SLE patients with and without HTLV-I infection. Our results suggest some involvement of HTLV-I in the pathogenesis of SLE.

Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus. Publishing Authors By Initials

M Akimoto,K Matsushita,Y Suruga,N Aoki,A Ozaki,K Uozumi,C Tei,N Arima,

For similar diagnosis: laboratory techniques and procedures: immunologic tests: serologic tests research abstracts see: diagnosis: laboratory techniques and procedures: immunologic tests: serologic tests research

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Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of rheumatology

VOLUME: 34

Page Numbers: 1841-8

Journal Abbreviation: J. Rheumatol.

ISSN: 0315-162X

DAY: 1

MONTH: 08

YEAR: 2007

Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus. Information

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LANGUAGE: eng

NlmUniqueID: 7501984

Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus. Keywords Mesh Terms:

KEYWORDS: Serologic Tests

MESH TERMS: administration & dosage

Chemical & Substance for Abstract: Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus. Information

Substance Name: Prednisolone

Registry Number: 50-24-8

Grant and Affiliation Information for Clinical manifestations of human T lymphotropic virus type I-infected patients with systemic lupus erythematosus.

AFFILIATION: Department of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, Japan. akimoto@m3.kufm.kagoshima-u.ac.jp

Country: Canada

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MEDLINETA: J Rheumatol

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