Clinical manifestations and predictors of severe malaria in Indian children.

Clinical manifestations and predictors of severe malaria in Indian children. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Clinical manifestations and predictors of severe malaria in Indian children. Abstract Text:

Radha Tripathy,Sailajanandan Parida,Leena Das,Debi Prasad Mishra,Diptimayee Tripathy,Mangala Charan Das,Hegang Chen,James H Maguire,Pinaki Panigrahi,

OBJECTIVE: Although the greatest morbidity and mortality attributable to malaria occurs among children in Africa, up to one third of the world's malaria burden is borne by non-African countries, where levels of endemicity are lower. Because there are few published criteria for managing life-threatening malaria in children in these countries, we conducted a study of major syndromes and predictors of death among critically ill Indian children to identify factors that could be used to improve the approach to their treatment. METHODS: A prospective study was conducted at the pediatric ward of SCB Medical College in eastern India (Orissa). Baseline demographic data were collected on all of the patients with confirmed slide-positive falciparum malaria. Patients satisfying any 1 of the 2000 World Health Organization criteria for severe malaria were included in the analysis. Prevalence of and mortality as a result of major symptoms were calculated followed by multiple regression modeling to identify major predictors of death. RESULTS: Of 1682 confirmed cases of malaria during a 32-month period, 374 subjects met the World Health Organization criteria for severe malaria. The case fatality rate was 12% in this series. Multiple regression analysis identified respiratory distress, coma, multiple organ dysfunctions, and hyperparasitemia as major predictors of death. Anemia and jaundice did not emerge as important markers of mortality. Many patients presented with multiple major complications, and the mortality rate was consistently high when >1 major predictor was present in a patient. CONCLUSIONS: Clinical features in Indian children differed from those reported in most studies that involved an African population. Multiple organ dysfunctions emerged as an important presenting feature and a new predictor of death in childhood malaria.

Clinical manifestations and predictors of severe malaria in Indian children. Publishing Authors By Initials

R Tripathy,S Parida,L Das,DP Mishra,D Tripathy,MC Das,H Chen,JH Maguire,P Panigrahi,

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

PUBMED ID PMID:

MEDLINE DATE:

Clinical manifestations and predictors of severe malaria in Indian children. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Pediatrics

VOLUME: 120

Page Numbers: e454-60

Journal Abbreviation: Pediatrics

ISSN: 1098-4275

DAY: 3

MONTH: Sep

YEAR: 2007

Clinical manifestations and predictors of severe malaria in Indian children. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376422

Clinical manifestations and predictors of severe malaria in Indian children. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: mortality

Chemical & Substance for Abstract: Clinical manifestations and predictors of severe malaria in Indian children. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Clinical manifestations and predictors of severe malaria in Indian children.

AFFILIATION: Center for Research on Maternal and Childhood Malaria, SCB Medical College, Cuttack, Orissa, India.

Country: United States

AGENCY: United States FIC

GRANT: TW 00601

ACRONYM: TW

MEDLINETA: Pediatrics

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Clinical manifestations and predictors of severe malaria in Indian children Related Publications

• Clinical manifestations and predictors of severe malaria in Indian children.
• Frontal intradiploic angioleiomyoma.
• HBAT: A Complete Package for Analysing Strong and Weak Hydrogen Bonds in Macromolecular Crystal Structures.
• Hybrid cardiac surgical procedure: technique and anaesthetic management.
• In vitro biocompatibility of equal channel angular processed (ECAP) titanium.
• In vitro fibroblast response to ultra fine grained titanium produced by a severe plastic deformation process.
• Prevalence and antimicrobial susceptibility pattern of extended-spectrum beta-lactamase-producing Enterobacteriaceae in the United Arab Emirates.
• Rate of resolution of histologically verified intracranial tuberculomas.
• Strong and weak hydrogen bonds in protein-ligand complexes of kinases: a comparative study.
• Tetralogy of Fallot with rheumatic mitral stenosis: A case report.