Clinical involvement of the tonsillar immune system in IgA nephropathy.

Clinical involvement of the tonsillar immune system in IgA nephropathy. Research Abstract Details 

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Clinical involvement of the tonsillar immune system in IgA nephropathy. Abstract Text:

Marie C Béné,Gilbert C Faure,Bruno Hurault de Ligny,Anne Kennel de March,

The temporal association of tonsillitis and hematuria or proteinuria in IgA nephropathy suggests that there might be a link between the physiological properties of the secondary lymphoid organ that tonsils represent and the mesangial deposition of IgA characteristic of this nephropathy. A number of clinical and ex-vivo data support this hypothesis. One of the earliest was the demonstration of the dimeric nature of mesangial IgA, composed of IgA monomers linked by a J chain, yet lacking the polyIg receptor acquired by secretory IgA during transcytosis through epithelial cells. This molecular structure is that of IgA synthesized in human tonsils, the epithelium of which lacks polyIg receptor. Moreover, tonsils from patients with IgA nephropathy display an abnormal partition of IgG and IgA producing plasma cells associated with a significantly developed web of high endothelial venules. IgA nephropathy could thus be in part related to an alteration of IgA precursors homing in tonsils. Tonsillectomy thus would present the advantage of removing an abnormally functioning source of dimeric IgA. Performed early enough in the course of the renal disease, tonsillectomy could suffice to halt the development of the nephropathy and restore the kidneys to health.

Clinical involvement of the tonsillar immune system in IgA nephropathy. Publishing Authors By Initials

MC Béné,GC Faure,B Hurault de Ligny,AK de March,

For similar surgical procedures, operative: otorhinolaryngologic surgical procedures: tonsillectomy research abstracts see: surgical procedures, operative: otorhinolaryngologic surgical procedures: tonsillectomy research

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Clinical involvement of the tonsillar immune system in IgA nephropathy. Journal Published:

PUBLICATION TYPE: Review

Journal: Acta oto-laryngologica. Supplementum

VOLUME:

Page Numbers: 10-4

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: Dec

YEAR: 2004

Clinical involvement of the tonsillar immune system in IgA nephropathy. Information

Number of References: 37

LANGUAGE: eng

NlmUniqueID: 370355

Clinical involvement of the tonsillar immune system in IgA nephropathy. Keywords Mesh Terms:

KEYWORDS: Tonsillectomy

MESH TERMS: immunology

Chemical & Substance for Abstract: Clinical involvement of the tonsillar immune system in IgA nephropathy. Information

Substance Name: Immunoglobulin A

Registry Number: 0

Grant and Affiliation Information for Clinical involvement of the tonsillar immune system in IgA nephropathy.

AFFILIATION: Laboratoire d'Inmunologie du CHU, Faculté de Médecine de Nancy, Vandoeuvre les Nancy, France. Marie-Christine.Bene@medicine.uhp-nancy.fr

Country: Norway

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MEDLINETA: Acta Otolaryngol Suppl

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