Clinical importance of HLA-DPB1 in haematopoietic cell transplantation.

Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Research Abstract Details 

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Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Abstract Text:

B E Shaw,T Gooley,J A Madrigal,M Malkki,S G E Marsh,E W Petersdorf,

There is increasing evidence for a significant effect of human leukocyte antigen (HLA)-DPB1 mismatching on complications following unrelated donor haematopoietic cell transplantation (HCT). In this analysis of 5930 patient/donor pairs, we found that a DPB1 mismatch predicted significantly for an increased risk of acute graft-vs-host disease [hazard ratio (HR): 1.33; P-value = <0.0001], while protecting against disease relapse (HR: 0.82, P-value = 0.01). These data support an immunogenic role for HLA-DPB1 in HCT and the need for pretransplant tissue typing at this locus.

Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Publishing Authors By Initials

BE Shaw,T Gooley,JA Madrigal,M Malkki,SG Marsh,EW Petersdorf,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research

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Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Tissue antigens

VOLUME: 69 Suppl 1

Page Numbers: 36-41

Journal Abbreviation:

ISSN: 0001-2815

DAY: 3

MONTH: Apr

YEAR: 2007

Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 331072

Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Keywords Mesh Terms:

KEYWORDS: Survival Rate

MESH TERMS: therapy

Chemical & Substance for Abstract: Clinical importance of HLA-DPB1 in haematopoietic cell transplantation. Information

Substance Name: HLA-DPB1

Registry Number: 0

Grant and Affiliation Information for Clinical importance of HLA-DPB1 in haematopoietic cell transplantation.

AFFILIATION: Department of Haematology, Nottingham City Hospital, Nottingham, UK. bshaw@doctors.org.uk

Country: Denmark

AGENCY: United States NIAID

GRANT: AI33484

ACRONYM: AI

MEDLINETA: Tissue Antigens

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