Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia.

Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia. Research Abstract Details 

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Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia. Abstract Text:

Francesc Bosch,Ana ,Eva ,Ana ,Neus Villamor,Carolina Moreno,Marta Crespo,Emili Montserrat,Francesc Bosch,Ana ,Eva ,Ana ,Neus Villamor,Carolina Moreno,Marta Crespo,Emili Montserrat,

Chronic lymphocytic leukemia (CLL) is a disease with an extremely heterogeneous prognosis. Because of this and because of the lack of a truly effective therapy, treatment of CLL must be adapted to the individual risk of each patient. Over the last quarter of century, prognosis of patients with CLL has been based on clinical features. In the last few years a number of biological prognostic parameters have been identified. Among them, the expression of ZAP-70 in neoplastic B lymphocytes is increasingly being recognized as of paramount importance to predict outcome. Patients with a low percentage (<20%) of ZAP-70 positive neoplastic B lymphocytes have a much better prognosis that those with a higher proportion (>20%) of ZAP-70 positive neoplastic B lymphocytes.

Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia. Publishing Authors By Initials

F Bosch,A ,E ,A ,N Villamor,C Moreno,M Crespo,E Montserrat,F Bosch,A ,E ,A ,N Villamor,C Moreno,M Crespo,E Montserrat,

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Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia. Journal Published:

PUBLICATION TYPE: Review

Journal: Cytometry. Part B, Clinical cytometry

VOLUME: 70

Page Numbers: 214-7

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ISSN: 1552-4949

DAY: 15

MONTH: Jul

YEAR: 2006

Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia. Information

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LANGUAGE: eng

NlmUniqueID: 101235690

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Grant and Affiliation Information for Clinical implications of ZAP-70 expressionin chronic lymphocytic leukemia.

AFFILIATION: Department of Hematology and Laboratory of Experimental Hematology, Institute of Hematology and Oncology, Hospital Clínic, IDIBAPS, University of Barcelona, Barcelona, Spain.

Country: United States

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MEDLINETA: Cytometry B Clin Cytom

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