Clinical implications of metastatic lymph node ratio in gastric cancer.

Clinical implications of metastatic lymph node ratio in gastric cancer. Research Abstract Details 

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Clinical implications of metastatic lymph node ratio in gastric cancer. Abstract Text:

Caigang Liu,Ping Lu,Yang Lu,Huimian Xu,Shubao Wang,Junqing Chen,Caigang Liu,Ping Lu,Yang Lu,Huimian Xu,Shubao Wang,Junqing Chen,

BACKGROUND: The 5-year survival rate in patients with gastric cancer is still poor, and lymph node metastasis is considered one of the most important prognostic factors. However, there are controversies in the classification of lymph node metastasis in gastric cancer. This study was carried out to investigate whether the metastatic lymph node ratio is a reliable classification of lymph node metastasis in gastric cancer in Chinese. METHODS: 224 cases with gastric cancer with more than D1 dissection were retrospectively reviewed. The association between the total number of resected lymph nodes and the number of metastatic lymph nodes was determined. The prognostic value of the metastastic node ratio, defined as the ratio of the number of metastatic lymph nodes over the total number of resected lymph nodes, and the pN classification was assessed. RESULTS: The number of metastatic lymph node increased with the number of total resected lymph nodes. A Cox regression revealed that the metastatic node ratio, the number of metastatic nodes, histological type, and histological growth pattern independently influenced prognosis. The 5-year survival rates were 78%, 61%, 25%, 0% in cases with a metastastic node ratio of 0%, > 0% but < 40%, 40-80%, > 80%, respectively (P < 0.001), and were 78%, 62%, 38%, 0% in cases with gastric cancer histologically classified as pN0, pN1, pN2, pN3, respectively (P < 0.001). CONCLUSION: The metastatic lymph node ratio is a simple and useful independent prognostic factor. It may obviate possible confounding factors that are related to stage migration, and should be considered as an important component in the lymph node category.

Clinical implications of metastatic lymph node ratio in gastric cancer. Publishing Authors By Initials

C Liu,P Lu,Y Lu,H Xu,S Wang,J Chen,C Liu,P Lu,Y Lu,H Xu,S Wang,J Chen,

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Clinical implications of metastatic lymph node ratio in gastric cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BMC cancer

VOLUME: 7

Page Numbers: 200

Journal Abbreviation: BMC Cancer

ISSN: 1471-2407

DAY: 24

MONTH: 10

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Department of Oncology, First Affiliated Hospital of China Medial University, Shenyang, China. luping2999@yahoo.com.cn

Country: England

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MEDLINETA: BMC Cancer

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