Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit.

Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit. Research Abstract Details 

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Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit. Abstract Text:

Naoyuki Miyashita,Yasushi Obase,Kazunobu Ouchi,Kozo Kawasaki,Yasuhiro Kawai,Yoshihiro Kobashi,Mikio Oka,Naoyuki Miyashita,Yasushi Obase,Kazunobu Ouchi,Kozo Kawasaki,Yasuhiro Kawai,Yoshihiro Kobashi,Mikio Oka,

Community-acquired pneumonia (CAP) due to Mycoplasma pneumoniae is usually mild, but some cases develop a severe life-threatening pneumonia. To investigate the clinical features of severe M. pneumoniae pneumonia in adults admitted to an intensive care unit, a multi-centre CAP surveillance study was performed. Among all hospitalized CAP cases between January 2000 and December 2004, there were 227 cases with M. pneumoniae pneumonia without the complication of other pathogens. A total of 13 of the cases required admission to an intensive care unit because of acute respiratory failure (ARF), and the remaining 214 cases (non-ARF) were low to moderately severe. The clinical features of ARF cases were compared with those of non-ARF cases. The underlying conditions in both types of case were identical, whereas clinical findings on admission clearly differed between the two groups. A regimen of an antibiotic effective against M. pneumoniae was begun on average at 9.3 days after the onset of symptoms in ARF cases, which was significantly later than for non-ARF cases (P<0.0001). However, two of the ARF cases progressed to respiratory failure despite the fact that adequate antibiotics were initially administered within 3 days after the onset of symptoms. All ARF cases received corticosteroids with adequate antibiotics, and their condition improved promptly. These results indicate that the clinical features, excluding underlying conditions, clearly differed between severe M. pneumoniae pneumonia and low to moderately severe pneumonia. The delayed administration of adequate antibiotics may contribute to the severity of M. pneumoniae pneumonia. Early corticosteroid therapy with adequate antibiotics should be considered.

Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit. Publishing Authors By Initials

N Miyashita,Y Obase,K Ouchi,K Kawasaki,Y Kawai,Y Kobashi,M Oka,N Miyashita,Y Obase,K Ouchi,K Kawasaki,Y Kawai,Y Kobashi,M Oka,

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Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of medical microbiology

VOLUME: 56

Page Numbers: 1625-9

Journal Abbreviation: J. Med. Microbiol.

ISSN: 0022-2615

DAY: 23

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 224131

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AFFILIATION: 1Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Okayama 701-0192, Japan.

Country: England

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MEDLINETA: J Med Microbiol

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