Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation.

Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation. Research Abstract Details 

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Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation. Abstract Text:

Yuki Asano-Mori,Yoshinobu Kanda,Kumi Oshima,Shinichi Kako,Akihito Shinohara,Hideki Nakasone,Hiroyuki Sato,Takuro Watanabe,Noriko Hosoya,Koji Izutsu,Takashi Asai,Akira Hangaishi,Toru Motokura,Shigeru Chiba,Mineo Kurokawa,

Late cytomegalovirus (CMV) disease beyond day 100 after hematopoietic stem cell transplantation (HSCT) has become an increasing problem after the introduction of preemptive ganciclovir (GCV) administration. To clarify the risk factors and outcome for late CMV reactivation and disease, we retrospectively analyzed the records of 101 Japanese adult patients who underwent allogeneic HSCT between 1998 and 2005 at our hospital. Fifty-one developed late positive CMV antigenemia, with a cumulative incidence of 53%. Recipient CMV seropositivity, the use of alemtuzumab, chronic GVHD, and high-dose steroids were significantly associated with late positive antigenemia. Eight patients developed late CMV disease, with a cumulative incidence of 8%, including retinitis and gastrointestinal disease. None progressed to a fatal disease. The use of alemtuzumab was identified as an independent significant risk factor for late CMV disease, although it was not associated with increased non-relapse mortality. Among the 51 patients with late positive antigenemia, 28 had consistently less than three positive cells, 25 of whom showed negative conversion without antiviral agents. In conclusion, late CMV antigenemia appeared to develop frequently, especially in patients with profound immune suppression; however, a fatal outcome could be prevented by optimal preemptive therapy. Low-level antigenemia may not require antiviral treatments.

Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation. Publishing Authors By Initials

Y Asano-Mori,Y Kanda,K Oshima,S Kako,A Shinohara,H Nakasone,H Sato,T Watanabe,N Hosoya,K Izutsu,T Asai,A Hangaishi,T Motokura,S Chiba,M Kurokawa,

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Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of hematology

VOLUME: 87

Page Numbers: 310-8

Journal Abbreviation: Int. J. Hematol.

ISSN: 0925-5710

DAY: 5

MONTH: 03

YEAR: 2008

Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation. Information

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LANGUAGE: eng

NlmUniqueID: 9111627

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AFFILIATION: Department of Hematology & Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Country: United States

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MEDLINETA: Int J Hematol

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