Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study.

Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study. Research Abstract Details 

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Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study. Abstract Text:

OBJECTIVE: Our objective was to evaluate the efficacy of Synthetic Serum Substitute (Irvine Scientific--Materials Section, Santa Ana, CA), a globulin-enriched protein preparation containing human serum albumin for supplementation of IVF culture media. DESIGN: We retrospectively analyzed IVF cycles performed at MacDonald Womens Hospital between January 1992 and November 1994. IVF cycles were reviewed and classified according to the nature of protein supplementation used in the embryo culture medium. Three protein supplements utilized during this time period were compared: Synthetic Serum Substitute (SSS), Plasmanate (PL), and maternal serum (MS). RESULTS: Although clinical pregnancy rates among the three treatment groups were not statistically different, there was a definite trend toward a higher pregnancy rate with SSS supplementation (SSS, 38.2%; MS, 28.0%; and PL, 24.9%). Embryos grown in SSS-supplemented culture media had a significantly higher implantation rate (17.8 vs 10.4 and 10.3%, respectively, for MS and PL). Preliminary data also suggest that human embryo development and blastulation in vitro were enhanced by this protein supplement. CONCLUSIONS: The higher implantation rate with SSS suggests that it may be superior to both maternal serum and Plasmanate in supporting human embryo development in vitro. Whether blastocysts derived from PL- and SSS-supplemented media are able to implant and give rise to clinical pregnancies remains to be seen.

Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study. Publishing Authors By Initials

For similar proteins: albumins: serum albumin research abstracts see: proteins: albumins: serum albumin research

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Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of assisted reproduction and genetics

VOLUME: 13

Page Numbers: 23-31

Journal Abbreviation: J. Assist. Reprod. Genet.

ISSN: 1058-0468

DAY: 17

MONTH: Jan

YEAR: 1996

Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study. Information

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LANGUAGE: eng

NlmUniqueID: 9206495

Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study. Keywords Mesh Terms:

KEYWORDS: Serum Albumin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study. Information

Substance Name: plasma protein fraction

Registry Number: 55963-80-9

Grant and Affiliation Information for Clinical experience with synthetic serum substitute as a protein supplement in IVF culture media: a retrospective study.

AFFILIATION: Department of Obstetrics and Gynecology, Case Western Reserve University, Cleveland, Ohio 44106, USA.

Country: UNITED STATES

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MEDLINETA: J Assist Reprod Genet

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