[Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase]

[Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase] Research Abstract Details 

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[Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase] Abstract Text:

A Furnaga,H Tsuboi,H Okada,H Gohra,K Hamano,K Sugi,T Katoh,Y Fujimura,K Esato,

To evaluate the role of granulocyte elastase (GEL) at cardiopulmonary bypass (CPB), the plasma GEL level was measured in 24 patients who underwent elective cardiac surgery and 47 patients who underwent elective gastroenterological surgery. The cardiac surgical patients were divided into two groups: 5 patients with CPB less than 120 minutes (HL group), and 19 patients with CPB more than 120 minutes (HH group). The patients with gastro-enterological surgery were also divided into two groups: 15 patients with postoperative complications (GC group), and 32 patients without postoperative complications (GU group). All the patients of GU, HL and HH groups were alive. Two patients of GC group died because of multiple organ failure (MOF). The serum levels of GEL in both the HH group and the GC group remained higher than in the GU group at 6 postoperative day (POD). The high serum level of IL-8 gave rise to high serum level of GEL in the HH group, even after cardiac surgery. We assumed that anti-cytokine therapy and aggressive administration of Ulinastatin are useful against postoperative complications and that careful management is need after long CPB.

[Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase] Publishing Authors By Initials

A Furnaga,H Tsuboi,H Okada,H Gohra,K Hamano,K Sugi,T Katoh,Y Fujimura,K Esato,

For similar surgical procedures, operative: surgical procedures, elective research abstracts see: surgical procedures, operative: surgical procedures, elective research

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MEDLINE DATE:

[Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: [Zasshi] [Journal]. Nihon Ky?bu Geka Gakkai

VOLUME: 43

Page Numbers: 1716-9

Journal Abbreviation:

ISSN: 0369-4739

DAY: 14

MONTH: Oct

YEAR: 1995

[Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase] Information

Number of References:

LANGUAGE: jpn

NlmUniqueID: 19130180

[Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase] Keywords Mesh Terms:

KEYWORDS: Surgical Procedures, Elective

MESH TERMS: physiology

Chemical & Substance for Abstract: [Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase] Information

Substance Name: Pancreatic Elastase

Registry Number: EC 3.4.21.36

Grant and Affiliation Information for [Clinical evaluation of patients with cardiopulmonary bypass by plasma granulocyte elastase]

AFFILIATION: First Department of Surgery, School of Medicine, Yamaguchi University, Japan.

Country: JAPAN

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MEDLINETA: Nippon Kyobu Geka Gakkai Zassh

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