Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus.

Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus. Abstract Text:

S Collaud,T Warloe,O Jordan,R Gurny,N Lange,

Fluorescence diagnosis following oral administration of 5-aminolevulinic acid (5-ALA) has shown to enable the sensitive visualization of intestinal metaplasia, dysplasia and early carcinoma in Barrett's esophagus. Once being established, this technique will be a potential alternative to today's standard diagnosis, i.e. four-quadrant random biopsies which are taken every 1-2 cm of the esophagus for histopathological analysis. In order to further improve this methodology, topical application of lipophilic 5-ALA esters to the esophagus could be advantageous in terms of fluorescence contrast and fluorescence intensity in the target tissue, adverse side effects, as well as application time. Therefore, the aim of this study was to develop a bioadhesive formulation loaded with hexylaminolevulinate (HAL) targeting the esophageal lining. In the present study, different mucoadhesive gels including poloxamer 407, cross-linked polyacrylic acid, hydroxypropylmethylcellulose, sodium carboxymethylcellulose and chitosan have been evaluated with respect to bioadhesion to the esophagus using an ex vivo rat model and a clinical study on healthy volunteers. In order to visualize the mucoadhesive properties of the formulations, a blue dye was incorporated as contrast agent. Chitosan has shown the best esophageal adhesion both in vitro and in vivo. Furthermore, using the in vitro release profiles from chitosan loaded with 40 mM of HAL, one can estimate that after a residence time of 10 min on the esophageal wall, the amount of HAL delivered to the epithelium will be sufficient to perform fluorescence diagnosis of Barrett's esophagus following swallowing of this formulation.

Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus. Publishing Authors By Initials

S Collaud,T Warloe,O Jordan,R Gurny,N Lange,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of controlled release : official journal o

VOLUME: 123

Page Numbers: 203-10

Journal Abbreviation:

ISSN: 1873-4995

DAY: 23

MONTH: 08

YEAR: 2007

Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8607908

Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus.

AFFILIATION: Department of Pharmaceutics and Biopharmaceutics, School of Pharmaceutical Sciences, University of Geneva, Quai Ernest-Ansermet 30, 1211 Geneva 4, Switzerland.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Control Release

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus Related Publications

• A dictionary model for haplotyping, genotype calling, and association testing.
• Association with the presence of naive T cells in chronic myeloid leukemia patients after allogeneic human stem cell transplantation and the lower incidence of chronic graft-versus host disease and relapse.
• Breast tumor kinase (protein tyrosine kinase 6) regulates heregulin-induced activation of ERK5 and p38 MAP kinases in breast cancer cells.
• Cannabis and the lung.
• Clinical evaluation of bioadhesive hydrogels for topical delivery of hexylaminolevulinate to Barrett's esophagus.
• Congenitally blind humans use different stimulus selection strategies in hearing: An ERP study of spatial and temporal attention.
• Dopamine transporter, gender, and number of sexual partners among young adults.
• Genomewide weighted hypothesis testing in family-based association studies, with an application to a 100K scan.
• How to manage aortic arch complications after stenting of the descending aorta.
• How well are patients doing up to 30 years after a mustard operation?
• Impact of placing a conduit from the right ventricle to the pulmonary arteries as the first stage of further palliation in the Norwood sequence for hypoplasia of the left heart.
• Interventional techniques in cardiovascular surgery.
• Linkage of progestin and epidermal growth factor signaling: phosphorylation of progesterone receptors mediates transcriptional hypersensitivity and increased ligand-independent breast cancer cell growth.
• Measuring college students' alcohol consumption in natural drinking environments: field methodologies for bars and parties.
• Neuron numbers and volume of the amygdala in subjects diagnosed with bipolar disorder or schizophrenia.
• Novel growth stent for the permanent treatment of vessel stenosis in growing children: An experimental study.
• OC31: Women's satisfaction with the OSCAR (One-Stop Clinic Assessment of Risk) model of first-trimester combined screening.
• OP25.01: First trimester combined screening: prospective evaluation of performance in an OSCAR setting.
• On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice.
• Outcome after emergency surgery for acute perforated diverticulitis in 200 cases.
• P2BAT: a massive parallel implementation of PBAT for genome-wide association studies in R.
• Pharmacokinetics and pharmacodynamics of growth hormone in patients on chronic haemodialysis compared with matched healthy subjects: an open, nonrandomized, parallel-group trial.
• Primique: automatic design of specific PCR primers for each sequence in a family.
• Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells.
• Roles for fructose-2,6-bisphosphate in the control of fuel metabolism: beyond its allosteric effects on glycolytic and gluconeogenic enzymes.
• Stable expression of AtGA2ox1 in a low-input turfgrass (Paspalum notatum Flugge) reduces bioactive gibberellin levels and improves turf quality under field conditions.
• The relationship between alcohol use and cigarette smoking in a sample of undergraduate college students.
• Update of the European standards for inactive surgical implants in the area of heart valve prostheses.
• [Clinical diagnostics of pulmonary tuberculosis]
• [Oat products in gluten free diet]