Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis.

Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis. Abstract Text:

The clinical course of 15 patients with Wegener's granulomatosis (WG) and eight patients with microscopic polyangiitis (MPA) from one nephrological clinical center is presented for the period from 1984 to 1993, when testing for antineutrophil cytoplasmic antibodies (ANCA) was gradually introduced into routine clinical practice. We found a high degree of prolonged time periods with symptoms attributable to WG or MPA until the specific diagnosis was made. Nine patients with WG and one patient with MPA had symptomatic prediagnostic periods of more than three years, which extended in one case up to twenty years. In these prediagnostic periods, often even severe flares of vasculitic activity resulted in spontaneous remission without immunosuppressive therapy. One patient on chronic dialysis for four months because of rapidly progressive glomerulonephritis, experienced sufficient spontaneous regain of residual renal function to stay off dialysis for 6 years. Despite a high amount of spontaneous recovery, recurrent flares of disease eventually led to death in those cases without sufficient immunosuppressive therapy. Contrary to long courses of disease, one patient with WG had a fulminate exacerbation of disease with lethal hemoptysis after a prediagnostic period of only three months. Renal disease, respiratory and other symptoms did not occur sequentially, but each could precede the other. We conclude in agreement with published former experience, that WG and MPA show a highly variable spontaneous disease course, that requires extended observational periods for evaluating maintenance therapies.

Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Renal failure

VOLUME: 20

Page Numbers: 519-32

Journal Abbreviation: Ren Fail

ISSN: 0886-022X

DAY: 21

MONTH: May

YEAR: 1998

Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701128

Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis. Keywords Mesh Terms:

KEYWORDS: Wegener Granulomatosis

MESH TERMS: therapy

Chemical & Substance for Abstract: Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis. Information

Substance Name: Cyclophosphamide

Registry Number: 50-18-0

Grant and Affiliation Information for Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis.

AFFILIATION: Medical Department A, Hospital of Ludwigshafen, Academic Teaching Center of the Johannes-Gutenberg University Mainz, Bremserstrabe, Germany.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Ren Fail

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis Related Publications

• A systematic, data-driven approach to the combined analysis of microarray and QTL data.
• Activation of Rap1B by G(i) family members in platelets.
• American and German students' knowledge, perceptions, and behaviors with respect to over-the-counter pain relievers.
• Assessment of early deterioration.
• Automatically controlled air-bubble trap for use in haemodialysis.
• CLINICAL TRIAL OF INHALED ERGOTAMINE TARTRATE IN MIGRAINE.
• Cardiovascular biology. Small cells, big issues.
• Clinical course and symptomatic prediagnostic period of patients with Wegener's granulomatosis and microscopic polyangiitis.
• Clinical trial of methyl cysteine hydrochloride in chronic bronchitis.
• Cross-talk of instructed and applied arbitrary visuomotor mappings.
• Does the Human Motor System Simulate Pinocchio's Actions? Coacting With a Human Hand Versus a Wooden Hand in a Dyadic Interaction.
• Endothelin and atrial natriuretic peptide in non-insulin-dependent diabetic versus nondiabetic patients on chronic hemodialysis.
• Fifty (or more) ways to leave your platelets (in a thrombus).
• Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons.
• Multiple disorders in the elderly. A clinical and statistical study.
• Peginterferon alfa-2b and weight-based or flat-dose ribavirin in chronic hepatitis C patients: a randomized trial.
• Problems in the measurement of child mortality where statistical systems are limited.
• Reconstitution of maltose transport in malB and malA mutants of Escherichia coli.
• Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury.
• What is matched in direct matching? Intention attribution modulates motor priming.
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]